Drug Metabolism Pt 4: Other Phase 1

Question 1

Alcohol Dehydrogenase & Aldehyde Dehydrogenase

perform:

alcohol oxidation/ aldehyde oxidation

of primary alcohols

draw the mechanism

Answer 1

Question 2

secondary alcohols are reduced to ketones by which enzyme?

Which enzyme performs reaction in reverse?

Answer 2

Alcohol dehydrogenase

Keto reductase

Question 3

Show the alcohol oxidation to a ketone reaction.

Answer 3

Question 4

Draw the reaction for an ester hydrolysis.

Answer 4

Question 5

Name some important characteristics of the ester hydrolysis reaction:

Answer 5

1. enzyme: esterases
2. very facile
3. usually terminates drug action
4. may yield active metabolites
5. excellent approach to prodrugs

Question 6

Amide Hydrolysis

Answer 6