Drug Metabolism Pt 3: P450 Phase 1 Flashcards
CYP450 P
Arene Oxides—Show the Formation of Phenols
Arene Oxides
show the Detoxification with GSH mechanism
Arene oxides
GSH detoxification occurs with what enzyme?
Glutathione S-Transferase
Show the Hydration with Epoxide Hydratase mechanism
Draw an example of P450 Hydroxylation
ortho/para hydroxylation is an example of ___
Electrophilic aromatic substitution
The enzyme that performs alkene epoxidation
Epoxide Hydrolase
Draw mechanism for alkene epoxidation
What happens during Benzylic Hydroxylation?
An aliphatic C is directly attached to an aromatic C (at the benzylic position):
Ketones are usually ______ to secondary alcohol
reduced
Show the omega hydroxylation (P450)
Ibuprofen can be reduced how?
Show the process for N-dealkylation
Show the O-dealkylation process
Show the process of S-dealkylation
Show the P450 Oxidation Deamination
Show the MAO Oxidative Deamination
Show how N oxidation happens at primary and secondary amines
Show how sulfide becomes converted into sulfone
S oxidation
What is this?
a simplified P450 schematic
Add the missing labels.
What is this?
heme center
Draw a simplified heme center.
