Drug Metabolism

Question 1

Drug metabolism is the ———— of drugs in the body transforming lipophilic agents into more ———, ——— products which can be easily ———

Answer 1

Chemical modification, polar, hydrophilic, excreted

Question 2

The main pathway for removal of drugs in the body is?

Answer 2

Drug metabolism

Question 3

Drug metabolism sometimes leads to chemical activation of inactive drugs to their active substrates. Eg of these drugs include?

Answer 3

Codeine to morphine, Enalpril to Enalprilat

Question 4

What are they outcomes of drug metabolism?

Answer 4

Inactivation, active metabolite, active drug

Question 5

Drugs are mainly hydrophilic. T/F

Answer 5

False

Question 6

Drug metabolism occurs mainly where?

Answer 6

Liver

Question 7

Drug metabolism involves only microsomal enzymes. T/F

Answer 7

False. Microsomal and Non-microsomal enzymes

Question 8

Apart from the liver what are other sites where Drug metabolism occurs?

Answer 8

GIT, kidney, lungs skin