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Clin Pharm > Drug List; Drug is Answer > Flashcards

Drug List; Drug is Answer Flashcards

1
Q

Immunemodulator

Mech of Action

  • Calcineurin inhibitor that binds to cytoplasmic receptor proteins.
  • inhibits calcineurin, & decreases expression of IL-2 and other cytokines necessary for T-cell activation.
A

Cyclosporine

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2
Q

Immunemodulator

Mech of Action
- Similar to cyclosporine but used topically

A

Tacrolimus

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3
Q

Immunemodulator

Mech of Action

  • Janus Kinase inhibitor
  • Inhibits activity of proinflammatory cytokines (IL-1, IL-4, IL-6, IL13, IL-31*).
A

Oclacitinib & Apoquel

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4
Q

Immunemodulator

Mech of Action

  • prodrug that is metabolized to a purine analog (6-mercapto purine).
  • Interferes w/ incorporation of purines or pyrimidines into DNA
A

Azathioprine

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5
Q

Immunemodulator

Mech of Action

  • alkylate DNA that causes chemical cross-links to occur in DNA
  • interferes w/ DNA replication.
  • None labeled for use in veterinary medicine.
A

Cyclophosphamide & Chlorambucil

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6
Q

Immunemodulator

Mech of Action

  • inhibits type II isoform of inosine-5’-monophosphate dehydrogenase present in activated lymphocytes.
  • inhibits synthesis of guanosine nucleotides.
  • may also suppress dendritic cell maturation and monocyte recruitment.
A

Mycophenolate mofetil & Mycophenolic Acid

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7
Q
  • Immunemodulator

- Anti-inflammatory used for reactive airway Dz (smooth muscle relax)

A

Corticosteroids

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8
Q

used for pulmonary hypertension

Mech of Action

  • type V phosphodiesterase inhibitor
  • produces nitric oxide mediated vasodilation
A

Slidenafil

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9
Q

Anti-inflammatory used for reactive airway Dz

MOA

  • interferes w/ Ca transport across cell membrane
  • inhibits mast cell degranulation
A

Cromolyn

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10
Q

Antitussive

MOA
- depresses cough center in medulla via mu or kappa receptor

A

Morphine, codeine, & hydrocodone

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11
Q

Expectorant

MOA

  • stimulate gastric mucosa & vagus
  • increase GI & bronchial secretions
A

Saline Expectorants

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12
Q

anti-tussive

MOA

  • depresses cough center in medulla via mu or kappa receptor
  • partial Mu agonist
A

Butorphanol

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13
Q

antitussive w/ seretonin & alpha-2 activity

A

Tramadol

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14
Q

stimulate resp center in emergency

MOA
- stimulatory affects on carotid & aortic chemoreceptors

A

Doxapram

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15
Q

bronchodilator

MOA

  • inhibition of PDE ->
  • inhibits breakdown of cAMP ->
  • decreased release of inflammatory mediators from mast cells ->
  • anti-inflammatory & bronchial smooth muscle relaxation.
  • ALSO adenosine receptor antagonists ->
  • avoid bradycardia and bronchoconstriction.
A

Methylxanthines

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16
Q

bronchodilator

MOA

  • stimulate alpha & beta 1 & 2 adrenergic receptors ->
  • hypertension & tachycardia
A

Epinephrine

17
Q

bronchodilator

MOA
- anticholinergic

A

Atropine
Glycopyrrolate
Ipratropium bromide

18
Q

bronchodilator

MOA

  • stimulate beta 1 & 2 adrenergic receptors ->
  • tachycardia
A

Isoproterenol

19
Q

bronchodilator

MOA
- agonist of beta-2 adrenergic receptors

A 
Terbutaline
Metaproterenol
Albuterol
Salmeterol
Clenbuterol
20
Q

decongestant

MOA
- agonist of alpha-1 receptors

A

Pseudoephedrine

21
Q

decongestant & urinary retention

MOA
- agonist of alpha-1 receptors

A

Phenylpropanolamine (PPA)

22
Q

Antibacterial Betalactams

MOA
Bind the bacterial transpeptidase interfering with the bacteria cell wall syntesis.

A

Time dependent

  • Cephalexin
  • Amoxicillin +/- clavulanic acid
  • Ampicillin +/- sulbactam
  • Cefadroxil
  • Cefovacin
  • Cefpodoxime
  • Cephalothin
  • Cephapirin
  • Cloxacillin
  • Imipenem or Meropenem
  • Oxacillin
  • Penicillin
  • Ticarcillin
23
Q

Antibacterial Aminoglicosides

MOA
Protein synthesis inhibitor (misfolded protein; 30s)

A

Conc. Dependent

  • Amikacin
  • Gentamicin
  • Neomycin sulfate
  • Tobramycin
24
Q

Antibacterial macrolide

MOA
Protein synthesis inhibitor (50s)

A

Bacteriostatic

  • Azithromycin
  • Erythromycin
  • Gamithromycin
  • Timicosin
  • Tylosin
25
Q

Antibacterial Tetracycline

MOA
Protein synthesis inhibitor (30s)

A

Bacteriostatic

  • Chlortetracycline
  • Oxytetracyline
  • Tetracycline
26
Q

Antibacterial Flouroquinolone

MOA
inhibit the bacterial DNA gyrase (topoisomerase II) enzyme which is necessary for transcription, translation and bacterial replication.

A

Conc. Dependent

  • Enrofloxacin
  • Marbofloxacin
  • Orbifloxacin
  • Pradofloxacin
27
Q

Antibacterial Anphenicol

MOA
Protein synthesis inhibitor (50s)

A

Bacteriostatic

  • Florphenicol
  • Thiamphenicol
28
Q

Antibacterial Lincosamide

MOA
Protein synthesis inhibitor (50s)

A

Bacteriostatic

- Lincomycin

29
Q

Antibacterial

MOA
A detergent-like action is responsible for disrupting gram-negative cell membranes. The cationic polymyxins interact with the anionic phospholipids (endotoxin) in the Gram-negative cell wall, disrupting cell wall.

A
  • Polymyxin B sulfate
30
Q

Antibacterial

MOA
Nucleic Acid Synthesis Inhibitor

A

Rifampin

31
Q

Bacteriostatic Antibacterial

MOA
Dihydriofolate reductase inhibitor

A

Trimethoprim

32
Q

Antibacterial

MOA
binds precursors of peptidoglycans interfering with bacterial cell wall synthesis.

A

time-dependent

  • Vancomysin
33
Q

Antibacterial / Antiparasitic

MOA
Long-term exposure to low concentrations reduces the level of replication of T. gondii,
Affects the protein synthesis of free parasites,
Impairs the ability of tachyzoites to infect host cells

A

Clindamycin

34
Q

Antibacterial / Antiparasitic

MOA
undefined, maybe free radicals syntesis

A

Metronidazole

35
Q

Antibacterial / Antiparasitic

MOA
Dihydropteroate synthase inhibitor

A

Bacteriostatic but cidal if combined w/ Ometroprim

  • Sulfadiazine
  • Sulfadimethoxine
  • Sulfamethizole
  • Sulfaquinoxaline
  • Sulfisoxazole

Clin Pharm (8 decks)

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