Drug list Flashcards
Phenelzine
MAOb inhibitor (irreversible) Aytpical depression
Buspirone
Partial agonist of 5HT1 receptor
Anxiolytic
Phenytoin
Na+ channel agonist Zero-order kinetics AED Liver enzyme induction - increase dose NOT to be used in absence seizures
Chlorpromazine
Typical antipsychotic
Post-synapytic dopamine antagonist
Treatment of schizophrenia
Clozapine
Atypical antipsychotic
Dopamine and 5-HT antagonist
D4 (and 5-HT)
Selegiline
MAO inhibitor (irreversible) Treatment of PD
Rasagiline
MAO inhibitor (irrevervsible)
Early stage PD
Can be used as adjunct therapy at a later stage
Diclofenac
NSAID
Cox1 and Cox2 inhibitor (non-selective)
Analgesic and anti-inflammatory
NOT to be used in those with heart conditions
Tramadol
Pain
Opioid Mu receptor antagonist (Ach m3 and 5-HT2 antagonist
Pregabalin
GABA-ergic anticonvulsant - acts on Ca2+ channels to increase extracellular concentration of GABA in the brain
CNS depressant
Epilepsy
Neuropathic pain
Phenobarbitone
Anticonvulsant
Phenobarbitone
Anticonvulsant
Epilepsy
Increase Cl- into the neurone to cause hyperpolarisation and increase the refractory period - reduced excitability of the neurone
Diazepam
Benzodiazepine
Positive allosteric modulator of GABAa - causes them to open more frequently
Epilepsy
Anxiolytic
Restless legs syndrome
Sodium valproate
Anticonvulsant
Blockage of Na+ channels to increase the levels of GABA (inhibitory)
Epilepsy
Bipolar
Domperidone !
Peripherally selective dopamine D2 antagonist - used to treat the peripheral side effects of D2 agonists when e.g. benzeraside is ineffective (nausea, vomiting)
PD
Moclobemide
MAO inhibitor - reversible
Selective for MAOa
Depression
Olanzapine
Atypical antipsychotic
SO dopamine and 5-HT antagonist with higher affinity for 5-HT
Schizophrenia
Bipolar
Alemtuzumab
MS
Amphetamine
CNS stimulant - increased release of monoamines from nerve terminals - prevents reuptake of monoamines
MDMA
Aphetamine - prevents reuptake of monoamines
Rotigotine
Dopamine agonist - transdermal patch
Not effective in later stages of PD
Fluoxetine
SSRI
Depression
Safe in overdose
Used in diabetics with depression - improvements in HBA1c
Mirtazapine
Noradrenaline and serotonin antagonist
Depression
Benzotropine
Anticholinergic muscarinic antagnoist
PD - hyperactivity of cholinergic neurones
Orphenadrine
Anticholinergic muscarinic antagonist (like benztropine)
Amantadine
Release of dopamine from presynaptic stores
PD
Entacapone
Inhibitor of COMT (used with L-dopa)
PD
Sumatriptan
Treatment of migraines
Selective agonist of 5-HT1
Ondandsteron
Selective 5-HT3 antagonist
Anti-emetic - nausea and vomiting
Carbamazepine
Sodium channel antagonist
Liver enzyme induction
Not to be used in absence seizures
AED