Drug list Flashcards by Umma Raja

Phenelzine

MAOb inhibitor (irreversible)
Aytpical depression

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Buspirone

Partial agonist of 5HT1 receptor

Anxiolytic

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Phenytoin

Na+ channel agonist 
Zero-order kinetics 
AED
Liver enzyme induction - increase dose 
NOT to be used in absence seizures

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Chlorpromazine

Typical antipsychotic
Post-synapytic dopamine antagonist
Treatment of schizophrenia

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Clozapine

Atypical antipsychotic
Dopamine and 5-HT antagonist
D4 (and 5-HT)

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Selegiline

MAO inhibitor (irreversible) 
Treatment of PD

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Rasagiline

MAO inhibitor (irrevervsible)
Early stage PD
Can be used as adjunct therapy at a later stage

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Diclofenac

NSAID
Cox1 and Cox2 inhibitor (non-selective)

Analgesic and anti-inflammatory
NOT to be used in those with heart conditions

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Tramadol

Pain

Opioid Mu receptor antagonist (Ach m3 and 5-HT2 antagonist

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Pregabalin

GABA-ergic anticonvulsant - acts on Ca2+ channels to increase extracellular concentration of GABA in the brain
CNS depressant

Epilepsy
Neuropathic pain

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Phenobarbitone

Anticonvulsant

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Phenobarbitone

Anticonvulsant
Epilepsy

Increase Cl- into the neurone to cause hyperpolarisation and increase the refractory period - reduced excitability of the neurone

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Diazepam

Benzodiazepine
Positive allosteric modulator of GABAa - causes them to open more frequently

Epilepsy
Anxiolytic
Restless legs syndrome

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Sodium valproate

Anticonvulsant
Blockage of Na+ channels to increase the levels of GABA (inhibitory)

Epilepsy
Bipolar

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Domperidone !

Peripherally selective dopamine D2 antagonist - used to treat the peripheral side effects of D2 agonists when e.g. benzeraside is ineffective (nausea, vomiting)

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Moclobemide

MAO inhibitor - reversible
Selective for MAOa

Depression

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Olanzapine

Atypical antipsychotic
SO dopamine and 5-HT antagonist with higher affinity for 5-HT

Schizophrenia
Bipolar

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Alemtuzumab

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Amphetamine

CNS stimulant - increased release of monoamines from nerve terminals - prevents reuptake of monoamines

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MDMA

Aphetamine - prevents reuptake of monoamines

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Rotigotine

Dopamine agonist - transdermal patch

Not effective in later stages of PD

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Fluoxetine

SSRI

Depression
Safe in overdose
Used in diabetics with depression - improvements in HBA1c

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Mirtazapine

Noradrenaline and serotonin antagonist

Depression

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Benzotropine

Anticholinergic muscarinic antagnoist

PD - hyperactivity of cholinergic neurones

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Orphenadrine

Anticholinergic muscarinic antagonist (like benztropine)

Amantadine

Release of dopamine from presynaptic stores PD

Entacapone

Inhibitor of COMT (used with L-dopa) PD

Sumatriptan

Treatment of migraines | Selective agonist of 5-HT1

Ondandsteron

Selective 5-HT3 antagonist Anti-emetic - nausea and vomiting

Carbamazepine

Sodium channel antagonist Liver enzyme induction Not to be used in absence seizures AED

Lamotrogine

Sodium channel antagonist (and calcium channel) - inhibition of glutamate release AED

Ethusuximide

Calcium channel antagonist Can be used in absence seizures AED

Gabapentin

Act on calcium channels to increase GABA levels AED

Memantine

NMDA glutamate antagonist Prevention of hyper-excitability of neurones Treatment of moderate AD

Rivastigmine

Acetylcholinesterase inhibitor Treatment of AD

Galantamine

Acetylcholinesterase inhibitor Treatment of AD

Donepezil

Acetylcholinesterase inhibitor Treatment of AD

Caffeine

CNS stimulant Adenosine receptor antagonist

Fingolimod

Glatiramer acetate

Natalizumab

Risperidone

Atypical antipsychotic - antagonist at dopamine and 5-HT receptors

Tetrabenzine

Huntington's chorea Synaptic vesicle amine transporter inhibitor

Zolpidem

Z-drug Treatment of insomnia

Flumazenil

GABAa antagonist Treatment of benzodiazepine overdose - short half life

Madopar

Contains L-dopa and benserazide Treatment of PD

L-dopa

Dopamine precursor L-dopa --> Dopamine via DOPA decarboxylase

Amitriptyline

Tricyclic antidepressant - inhibits the reuptake of amines Depression Neuropathic pain Dangerous in overdose

Citalopram

SSTI Depression Safe in overdose

Paracetamol

Selective cox-2 inhibitor Arachodonic acid --> prostaglandins via COX enzymes Analgesic, treatment of fever

Ibuprofen

Cox-1 and cox-2 inhibitor NSAID Analgesic and anti-inflammatory

Beta-interferons

Lorazepam

Benzodiazepine Anxiety, status epilepticus, sleep disorders

Benzeraside

Peripherally acting DOPA decarboxylase inhibitor | Cannot cross BBB

Carbamazepine

GABA receptor agonist and Na+ channel antagonist Inhibits hepatic enzymes AED Neuropathic pain

Cocaine

Increased monoamine levels Accumulation of dopamine in synaptic cleft CNS stimulant

Nicotine

Agonist at nicotinic Ach receptors

Temazepam

Benzodiazepine - short term Anxilytic Hypnotic

Amantadine

Inhibits dopamine reuptake and increases dopamine release

Ariprazole

Atypical antipsychotic

Baclofen

GABAb agonist for spasticity

Busproprion

Weak noradrenaline dopamine reuptake inhibitor Antidepressant

Carbidopa

DOPA decarboxylase inhibitor PD

Disulfiram

Inhibits alchohol metabolism Induces an acute sensitivity to alcohol for the treatment of chronic alcoholism

Flupenazine

Typical antipsychotic

Flupenthixol

Typical antipsychotic

Imipramine

TCA

Methysergide

Migraine and cluster headache

Phenobarbitone

GABAa agonist Anticonvulsant

Pramipexole

Dopamine agonist PD

Ropinirole

Dopamine agonist PD

Sertraline

SSRI

Deltra-tetrahydrocannabinol

CB1 receptor (partial agonist) for anorexia

Tiagabine (aka. gabatril)

Blocks GAT1 transporter to increase GABA Anticonvulsant - epilepsy

Tolcapone

COMT inhibitor PD

Agranulocytosis is the main adverse effect with usage of which drug?

Clozapine - atypical antipsychotic