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Year 2 BB > Drug list > Flashcards

Drug list Flashcards

1
Q

Phenelzine

A 
MAOb inhibitor (irreversible)
Aytpical depression
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2
Q

Buspirone

A

Partial agonist of 5HT1 receptor

Anxiolytic

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3
Q

Phenytoin

A 
Na+ channel agonist 
Zero-order kinetics 
AED
Liver enzyme induction - increase dose 
NOT to be used in absence seizures
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4
Q

Chlorpromazine

A

Typical antipsychotic
Post-synapytic dopamine antagonist
Treatment of schizophrenia

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5
Q

Clozapine

A

Atypical antipsychotic
Dopamine and 5-HT antagonist
D4 (and 5-HT)

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6
Q

Selegiline

A 
MAO inhibitor (irreversible) 
Treatment of PD
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7
Q

Rasagiline

A

MAO inhibitor (irrevervsible)
Early stage PD
Can be used as adjunct therapy at a later stage

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8
Q

Diclofenac

A

NSAID
Cox1 and Cox2 inhibitor (non-selective)

Analgesic and anti-inflammatory
NOT to be used in those with heart conditions

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9
Q

Tramadol

A

Pain

Opioid Mu receptor antagonist (Ach m3 and 5-HT2 antagonist

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10
Q

Pregabalin

A

GABA-ergic anticonvulsant - acts on Ca2+ channels to increase extracellular concentration of GABA in the brain
CNS depressant

Epilepsy
Neuropathic pain

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11
Q

Phenobarbitone

A

Anticonvulsant

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12
Q

Phenobarbitone

A

Anticonvulsant
Epilepsy

Increase Cl- into the neurone to cause hyperpolarisation and increase the refractory period - reduced excitability of the neurone

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13
Q

Diazepam

A

Benzodiazepine
Positive allosteric modulator of GABAa - causes them to open more frequently

Epilepsy
Anxiolytic
Restless legs syndrome

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14
Q

Sodium valproate

A

Anticonvulsant
Blockage of Na+ channels to increase the levels of GABA (inhibitory)

Epilepsy
Bipolar

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15
Q

Domperidone !

A

Peripherally selective dopamine D2 antagonist - used to treat the peripheral side effects of D2 agonists when e.g. benzeraside is ineffective (nausea, vomiting)

PD

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16
Q

Moclobemide

A

MAO inhibitor - reversible
Selective for MAOa

Depression

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17
Q

Olanzapine

A

Atypical antipsychotic
SO dopamine and 5-HT antagonist with higher affinity for 5-HT

Schizophrenia
Bipolar

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18
Q

Alemtuzumab

A

MS

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19
Q

Amphetamine

A

CNS stimulant - increased release of monoamines from nerve terminals - prevents reuptake of monoamines

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20
Q

MDMA

A

Aphetamine - prevents reuptake of monoamines

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21
Q

Rotigotine

A

Dopamine agonist - transdermal patch

Not effective in later stages of PD

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22
Q

Fluoxetine

A

SSRI

Depression
Safe in overdose
Used in diabetics with depression - improvements in HBA1c

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23
Q

Mirtazapine

A

Noradrenaline and serotonin antagonist

Depression

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24
Q

Benzotropine

A

Anticholinergic muscarinic antagnoist

PD - hyperactivity of cholinergic neurones

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25
Q

Orphenadrine

A

Anticholinergic muscarinic antagonist (like benztropine)

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26
Q

Amantadine

A

Release of dopamine from presynaptic stores

PD

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27
Q

Entacapone

A

Inhibitor of COMT (used with L-dopa)

PD

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28
Q

Sumatriptan

A

Treatment of migraines

Selective agonist of 5-HT1

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29
Q

Ondandsteron

A

Selective 5-HT3 antagonist

Anti-emetic - nausea and vomiting

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30
Q

Carbamazepine

A

Sodium channel antagonist
Liver enzyme induction
Not to be used in absence seizures

AED

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31
Q

Lamotrogine

A

Sodium channel antagonist (and calcium channel) - inhibition of glutamate release

AED

32
Q

Ethusuximide

A

Calcium channel antagonist
Can be used in absence seizures

AED

33
Q

Gabapentin

A

Act on calcium channels to increase GABA levels

AED

34
Q

Memantine

A

NMDA glutamate antagonist
Prevention of hyper-excitability of neurones

Treatment of moderate AD

35
Q

Rivastigmine

A

Acetylcholinesterase inhibitor

Treatment of AD

36
Q

Galantamine

A

Acetylcholinesterase inhibitor

Treatment of AD

37
Q

Donepezil

A

Acetylcholinesterase inhibitor

Treatment of AD

38
Q

Caffeine

A

CNS stimulant

Adenosine receptor antagonist

39
Q

Fingolimod

40
Q

Glatiramer acetate

41
Q

Natalizumab

42
Q

Risperidone

A

Atypical antipsychotic - antagonist at dopamine and 5-HT receptors

43
Q

Tetrabenzine

A

Huntington’s chorea

Synaptic vesicle amine transporter inhibitor

44
Q

Zolpidem

A

Z-drug

Treatment of insomnia

45
Q

Flumazenil

A

GABAa antagonist

Treatment of benzodiazepine overdose - short half life

46
Q

Madopar

A

Contains L-dopa and benserazide

Treatment of PD

47
Q

L-dopa

A

Dopamine precursor

L-dopa –> Dopamine via DOPA decarboxylase

48
Q

Amitriptyline

A

Tricyclic antidepressant - inhibits the reuptake of amines

Depression
Neuropathic pain
Dangerous in overdose

49
Q

Citalopram

A

SSTI

Depression
Safe in overdose

50
Q

Paracetamol

A

Selective cox-2 inhibitor
Arachodonic acid –> prostaglandins via COX enzymes

Analgesic, treatment of fever

51
Q

Ibuprofen

A

Cox-1 and cox-2 inhibitor
NSAID

Analgesic and anti-inflammatory

52
Q

Beta-interferons

53
Q

Lorazepam

A

Benzodiazepine

Anxiety, status epilepticus, sleep disorders

54
Q

Benzeraside

A

Peripherally acting DOPA decarboxylase inhibitor

Cannot cross BBB

55
Q

Carbamazepine

A

GABA receptor agonist and Na+ channel antagonist
Inhibits hepatic enzymes

AED
Neuropathic pain

56
Q

Cocaine

A

Increased monoamine levels
Accumulation of dopamine in synaptic cleft
CNS stimulant

57
Q

Nicotine

A

Agonist at nicotinic Ach receptors

58
Q

Temazepam

A

Benzodiazepine - short term

Anxilytic
Hypnotic

59
Q

Amantadine

A

Inhibits dopamine reuptake and increases dopamine release

60
Q

Ariprazole

A

Atypical antipsychotic

61
Q

Baclofen

A

GABAb agonist for spasticity

62
Q

Busproprion

A

Weak noradrenaline dopamine reuptake inhibitor

Antidepressant

63
Q

Carbidopa

A

DOPA decarboxylase inhibitor

PD

64
Q

Disulfiram

A

Inhibits alchohol metabolism

Induces an acute sensitivity to alcohol for the treatment of chronic alcoholism

65
Q

Flupenazine

A

Typical antipsychotic

66
Q

Flupenthixol

A

Typical antipsychotic

67
Q

Imipramine

68
Q

Methysergide

A

Migraine and cluster headache

69
Q

Phenobarbitone

A

GABAa agonist

Anticonvulsant

70
Q

Pramipexole

A

Dopamine agonist

PD

71
Q

Ropinirole

A

Dopamine agonist

PD

72
Q

Sertraline

73
Q

Deltra-tetrahydrocannabinol

A

CB1 receptor (partial agonist) for anorexia

74
Q

Tiagabine (aka. gabatril)

A

Blocks GAT1 transporter to increase GABA

Anticonvulsant - epilepsy

75
Q

Tolcapone

A

COMT inhibitor

PD

76
Q

Agranulocytosis is the main adverse effect with usage of which drug?

A

Clozapine - atypical antipsychotic

Year 2 BB (36 decks)

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