20. Memory and amnesia Flashcards

1
Q

What is meant by ‘learning’ and ‘memory’ and how are these inter-related?

A

Learning - A process by means of which organisms acquire new knowledge or skills
Memory - the maintenance of such learning across time

Learning and memory are both inferred from changes in behaviour

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2
Q

What are the different types of long term memory?

A

Declarative (explicit) memory

Non-declarative (implicit) memory

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3
Q

What is ‘declarative memory’?

A

Aka. episodic memory

This is the conscious, intentional, recollection of factual information, previous experiences and concepts

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4
Q

What are the different types of declarative memory?

Briefly describe these

A

Episodic memory - this is going back in time to remember personal events
Semantic memory - recalling general facts and facts about the world e.g. what is 2+2

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5
Q

What is ‘non-declarative memory’?

A

Aka. explicit memory and the most common type is procedural memory
This is memory acquired and used unconsciously - skills and behaviours e.g. how to perform a dance
This memory form is hard to report but is much easier to show to someone

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6
Q

What regions of the brain are involved in declarative memory?

A

Episodic - hippocampus, medial temporal lobe, neocortex

Semantic - lateral and anterior temporal cortex, prefrontal cortex

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7
Q

What regions of the brain are involved in non-declarative memory?

A

Procedural - striatum, cerebellum, motor cortex

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8
Q

Describe short term memory and how it differs to long term memory

What evidence is there to support this compared to long term memory?

A

Short term memory involves holding a small amount of information in the mind in an active, readily available state for a short period of time
This form is not related to learning and memory

Patients with frontal vs temporal lobe lesions - they show there is an independent way in which short term and long term memories are stored

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9
Q

What is spatial memory and which region of the brain is involved in this?

A

This is memory responsible for recording information based on one’s environment and spatial orientation

The hippocampus is involved in this - cab drivers have a larger hippocampus to normal

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10
Q

What is amnesia and what are the different classifications?

A

Amnesia is a partial or total loss of memory

Anterograde amnesia
Retrograde amnesia
Dissociative amnesia

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11
Q

Define anterograde amnesia

A

Form of amnesia where new events are not transferred to long term memory
Is a deficit in learning subsequent to the onset of the disorder
Damage to the hippocampus can result in this (Henry M)

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12
Q

Define retrograde amnesia

A

Form of amnesia where someone will be unable to recall events that occurred prior to the onset of amnesia

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13
Q

Define dissociative amnesia

A

Characterised by a blocking out of critical personal information, usually of a traumatic or stressful nature

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14
Q

What can cause amnesia?

A

Generally due to brain injury related to physical trauma, infections, drug and alcohol abuse or reduced blood flow to the brain (vascular insufficiency)
Infections can also result - that cause damage to the brain tissue

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15
Q

What other diseases is memory impairment prominent in?

A

Neurodegenerative diseases e.g. Alzheimer’s

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16
Q

What is long term potentiation?

A

This is a long lasting strengthening of synapses between nerve cells based on recent patterns of activity
Memories are thought to be encoded by this modification of synaptic strength - LTP is one of the major cellular mechanisms thought to be involved in learning and memory
Underlies neuronal plasticity

17
Q

Which receptors are involved in long term potentiation?

A

NMDA receptors - these are the receptors at the heart of learning, memory and amnesia
These are glutamate receptors and two ligands are required for their activation

18
Q

What is long term depression?

A

This is the opposite of long term potentiation

This is an activity dependent reduction in the efficacy of neuronal synapses following long patterned stimulus