Drug keyword definitions

Question 1

Bio-availability

Answer 1

The amount of unchanged drug from the original dose which reaches the systemic circulation.

Question 2

Buccal

Answer 2

Deposited under the lip

Question 3

Sublingual

Answer 3

Deposited under the tongue

Question 4

Oral

Answer 4

Drug is swallowed

Question 5

Rectal

Answer 5

Supppository up the bum

Question 6

Sustained release preparation

Answer 6

Sustained-release dosage forms are dosage forms designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects

Question 7

Solution

Answer 7

A solution is a mixture of ions or molecules (very, very small)

Question 8

Suspension

Answer 8

A suspension has bigger particle sizes and so it may look cloudy or murky

Question 9

Enteric coated tablets

Answer 9

Enteric coating delays disintegration of the tablet until it reaches the small intestine

Question 10

Phase 1 metabolism

Answer 10

Involves reactions such as oxidation, reduction and hydrolysis and results in division of the parent drug into active or inactive metabolites

Question 11

Prodrug

Answer 11

Inactive parent drug

Question 12

Phase 2 Metabolism

Answer 12

Involves conjugation reactions which aim to add functional groups to metabolites in order to increase their polarity and therefore, their solubility and excretion.

Question 13

CYTP450

Answer 13

Superfamily of oxidases