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ESAR 3.4 Exam 2 > Drug Interactions (Quiz) > Flashcards

Drug Interactions (Quiz) Flashcards

1
Q

Ramipril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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2
Q

Quinapril

A

Antacid: Reduce absorption

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3
Q

Lisinopril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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4
Q

Enalapril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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5
Q

Benazepril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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6
Q

Doxazosin

A

CYP3A4 inhibitor: decreased metabolism

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7
Q

Hydrochlorothiazide

A

Dofetilide: Increased risk of QTc prolongation

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8
Q

digoxin

A

P-glycoprotein inhibitor

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9
Q

Verapamil

A

Moderate CYP3A4 inhibitor

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10
Q

Diltiazem

A

Strong CYP3A4 inhibitor

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11
Q

Gemfibrozil

A

HMG-CoA Reductase Inhibitors: increased risk of myopathy or rhabdomyolysis

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12
Q

Fenofibrate

A

Warfarin: increased risk of bleeding

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13
Q

Ezetimibe

A

Warfarin: increased risk of bleeding

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14
Q

Simvastatin

A

Major CYP3A4 substrate

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15
Q

Rosuvastatin

A

Antacids: reduce absorption

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16
Q

Pravastatin

A

Bile acid-binding resins: reduce absorption

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17
Q

Lovastatin

A

Fibrate/niacin: Increased risk of myopathy or rhabdomyolysis

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18
Q

Olopatadine

A

No clinically significant interactions

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19
Q

Loratadine

A

CNS Depressants: increased risk of sedation

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20
Q

Promethazine

A

CNS Depressants: increased risk for sedation

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21
Q

Meclizine

A

CNS depressants: increased sedation

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22
Q

nystatin

A

No clinically significant interactions

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23
Q

Ketoconazole

A

No major drug interactions

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24
Q

Naproxen

A

Anticoagulants and antiplatelets: increased bleeding risk

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25
Q

Meloxicam

A

Warfarin: increased risk of bleeding

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26
Q

Ibuprofen

A

Antihypertensives: decreased efficacy

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27
Q

Diclofenac

A

Warfarin: increased risk of bleeding

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28
Q

Omeprazole

A

Clopidogrel: inhibits metabolism of clopidogrel to active form

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29
Q

Lansoprazole

A

Clopidogrel: Co-administration with Prevacid® inhibits metabolism of clopidogrel to active form

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30
Q

Ranitidine

A

pH-dependent drugs: ranitidine reduces absorption

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31
Q

warfarin

A

NSAIDs: increased risk of bleeding

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32
Q

enoxaparin

A

NSAIDs: may increase the chance of bleeding

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33
Q

Rivaroxaban

A

Antiplatelet agents: increased bleeding risk

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34
Q

Dabigatran

A

P-gp inducers: avoid coadministration with Pradaxa

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35
Q

Ticagrelor

A

NSAIDs: increased bleeding risk

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36
Q

Clopidogrel

A

CYP2C19 inhibitors: decreased clopidogrel activation

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37
Q

Folic acid

A

none

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38
Q

Levalbuterol

A

Non-selective beta blockers: decreased effectiveness of Xopenex

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39
Q

Albuterol

A

Non-selective beta blockers: decreased albuterol effect

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40
Q

Oseltamivir

A

Live influenza vaccine: administer 2 weeks prior or 48 hours after

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41
Q

Nitroglycerin

A

Phosphodiesterase inhibitors: excessive hypotension

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42
Q

tiotropium

A

Anticholinergics: additive effect

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43
Q

fluticasone+salmeterol

A

Non-selective beta blockers: decreased effectiveness of salmeterol

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44
Q

Budesonide+formoterol

A

Non-selective beta blockers: decreased effectiveness of formoterol

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45
Q

Prednisone

A

Fluoroquinolones: Increased risk of tendon rupture

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46
Q

Methylprednisolone

A

Fluoroquinolones: Increased risk of tendon rupture

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47
Q

Mometasone

A

CYP3A4 inducers/inhibitors: decreased/increased plasma levels of Asmanex

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48
Q

Levothyroxine

A

warfarin, al, ca, mg, fe

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49
Q

Risedronate

A

Aluminum, calcium, magnesium, iron

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50
Q

Alendronate

A

mg, ca, al, fe

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51
Q

Sildenafil

A

alpha blockers and nitrates: hypotension

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52
Q

metronidazole

A

ethanol: disulfiram like reaction; warfarin: increased bleeding risk

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53
Q

Minocycline

A

Aluminum, calcium, magnesium, iron: decreased minocycline absorption due to chelation

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54
Q

Penicillin

A

Probenecid: increases penicillin concentrations

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55
Q

Clarithromycin

A

QTC interval prolonging agents: additive effects on internal; major substrates and inhibitors of cyp3a4

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56
Q

azithromycin

A

QTC interval prolonging agents: additive effects on internal; major substrates and inhibitors of cyp3a4

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57
Q

Vardenafil

A

Nitrates and Alpha-blockers

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58
Q

tadalafil

A

Nitrates and Alpha-blockers

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59
Q

Humalog (lispro)

A

Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia

60
Q

Novolog (aspart)

A

Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia

61
Q

Lantus (glargine)

A

Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia

62
Q

Levemir (detemir)

A

Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia

63
Q

Glimepiride

A

Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia

64
Q

Saxagliptin

A

Major CYP3A4 substrate

65
Q

Metformin

A

Iodine

66
Q

tamsulosin

A

BBs, CCBs: increased risk of hypotension

67
Q

Tolterodine

A

QTc interval-prolonging agents: additive effects on QTc interval

68
Q

Solifenacin

A

QTc interval-prolonging agents: additive effects on QTc interval

69
Q

Nabumetone

A

Anticoagulants and antiplatelets: increased bleeding risk; Antihypertensives: decreased efficacy

70
Q

celecoxib

A

Antihypertensives: decreased efficacy; Anticoagulants and antiplatelets: increased bleeding risk

71
Q

Baclofen

A

CNS depressants

72
Q

Cyclobenzaprine

A

Anticholinergic drugs

73
Q

Methocarbamol

A

CNS depressants

74
Q

Tizanidine

A

CNS depressants

75
Q

Fentanyl

A

Benzodiazepines

76
Q

Tramadol

A

CYP2D6 inhibitors and inducers

77
Q

Morphine

A

CNS depressants

78
Q

Methadone

A

QTc prolonging drugs

79
Q

Oxycodone

A

Benzodiazepines

80
Q

Codeine / Acetaminophen

A

CYP2D6 inhibitors and inducers

81
Q

Percocet (Oxycodone/APAP)

A

CYP3A4 inducers and inhibitors

82
Q

Buprenorphine + Naloxone

A

Opioid antagonists/agonists

83
Q

Gabapentin

A

CNS depressants

84
Q

Lamotrigine

A

Estrogen based contraceptives, enzyme inducers rifampin and carbamazepine

85
Q

Levetiracetam

A

None

86
Q

Divalproex

A

Carbapenems

87
Q

Phenytoin

A

CYP3A4 substrates

88
Q

Pregabalin

A

CNS depressants

89
Q

Topiramate

A

Carbonic anhydrase inhibitors

90
Q

Glipizide

A

Fluoroquinolones

91
Q

Glyburide

A

Beta-blockers

92
Q

Nitrofurantoin

A

Norfloxacin

93
Q

Valacyclovir

A

Varicella and zoster virus vaccine

94
Q

Ropinirole

A

CYP1A2 inducers

95
Q

Memantine

A

none

96
Q

Sumatriptan

A

Monoamine oxidase inhibitors

97
Q

Tylenol

A

Warfarin

98
Q

Risperidone

A

CYP2D6 inhibitors

99
Q

Amitriptyline

A

CYP2D6 inhibitors

100
Q

Mirtazapine

A

CYP3A4 inhibitors and inducers

101
Q

Quetiapine

A

CYP3A4 inducers and inhibitors

102
Q

Olanzapine

A

CYP1A2 inducers and inhibitors

103
Q

Aripiprazole

A

Dopamine agonists

104
Q

Phenelzine

A

Sympathomimetics

105
Q

Bupropion

A

CYP2D6 inhibitors

106
Q

Paroxetine

A

MAOIs

107
Q

Escitalopram

A

Antiplatelet drugs

108
Q

Venlafaxine

A

Anticoagulants

109
Q

Citalopram

A

CYP3A4 inhibitors

110
Q

Duloxetine

A

MAOIs

111
Q

Sertraline

A

Anticoagulants

112
Q

Methylphenidate

A

MAOIs

113
Q

Amphetamine

A

MAOIs

114
Q

Phentermine

A

MAOIs

115
Q

Lisdexamfetamine

A

MAOIs

116
Q

Zolpidem

A

CNS depressants

117
Q

Temazepam

A

Oxycodone

118
Q

Trazodone

A

Linezolid

119
Q

Buspirone

A

MAOIs

120
Q

Lorazepam

A

Valproate

121
Q

Alprazolam

A

CYP3A4 inhibitors

122
Q

Benztropine

A

Tiotropium (anticholinergic)

123
Q

Diazepam

A

CNS depressants

124
Q

Clonazepam

A

CYP3A4 inhibitors

125
Q

Ferrous sulfate

A

Bisphosphonates

126
Q

Etanercept

A

Immunosuppressants

127
Q

Esomeprazole

A

Drugs that require acidic pH for absorption (eg. atazanavir)

128
Q

Adalimumab

A

Live vaccines

129
Q

Protonix

A

Clopidogrel

130
Q

Tretinoin

A

Photosensitizing agents

131
Q

Hydroxychloroquine

A

Mefloquine

132
Q

Ondansetron

A

CYP3A4 inducers

133
Q

Allopurinol

A

Pegloticase

134
Q

Metoclopramide

A

Dopamine agonists

135
Q

Methotrexate

A

NSAIDs

136
Q

Travoprost

A

None

137
Q

Mupirocin

A

None

138
Q

Latanoprost

A

None

139
Q

Phenazopyridine

A

None

140
Q

Dicyclomine

A

Potassium citrate

141
Q

hydrocodone/acetaminophen

A

CNS depressants

142
Q

Darunavir

A

Lovastatin

143
Q

bictegravir/emtricitabine/tenofovir alafenamide

A

Calcium supplements

144
Q

Symtuza

A

Carbamazepine

145
Q

Genvoya

A

Mometasone

146
Q

Dolutegravir

A

Dofetilide

147
Q

Odefsey

A

Proton pump inhibitors

ESAR 3.4 Exam 2 (5 decks)

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