Drug interactions Flashcards
1
Q
P450 Inducers
A
CRAPS
- Carbamazepine
- Rifampicin
- bArbiturates
- Phenytoin
- St. Johns Waort
2
Q
P450 Inhibitors
A
Some Certain Silly Compounds Annoyingly Inhibit Enzymes Grrrrr
- Sodium valproate
- Ciprofloxacin
- Sulphonamide
- Cimetidine/Omeprazole
- Antifungals, amiodarone
- Isioniazid
- Erythromycin/Clarithromycin
- Grapefruit
3
Q
Drugs affected by P450 inducers/inhibitors
A
- Warfarin
- COCP
- Theophylline
- Corticosteroids
- Tricyclics
- Statins
4
Q
Metformin & Cimetidine
A
Inhibits renal elimination
5
Q
Gentamicin & Loop diuretics
A
Renal Failure risk
6
Q
ACEI & Potassium-sparing diuretics
A
Hyperkalaemia
7
Q
ACEI & Metformin
A
Enhance hypoglycamic effect
8
Q
Statin & Amiodarone
A
Incr risk statin concentration and therefore risk of rhado
9
Q
Thiazide & PPI
A
Hyponatraemia
10
Q
Thiazide & Lithium
A
increase toxicity
11
Q
Drugs with narrow therapeutic windows
A
Guys with large dongles totally make perfect internet connections
- Gentamicin
- Warfarin
- Lithium
- Digoxin
- Theophylline
- Methotrexate
- Phenytoin
- Insulin
- Ciclosporin
