Atherosclerosis and lipid lowering drugs Flashcards

1
Q

Drug induced dyslipidaemia may be caused by

A
  • BB
  • Thiazides
  • Corticosteroids
  • Retinoids - Monitor
  • OC
  • Anti-HIV
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2
Q

Statins MOA

A

HMG-CoA Reductase inhibitors

  • Reduce plasma cholesterol; upregelation of heptic LDL receptoors, promoting LDL uptake
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3
Q

Statins are less effective in:

A

Homozygous familial hypercholesterolaemia. Can not make LDL receptors. Not a problem in heterozygous disease

Atorvastatin may be effective

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4
Q

When to take statins

A

At night, offsets a nocturnal increase in cholestereol synthsis

except atorastatin

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5
Q

When and how to prescribe atorvastatin

A

PRIMARY

>10% risk of CV over next 10 years (Qrisk)

  • 20mg atorvastatin. Low intensity

SECONDARY/PTS with CVD

  • 80mg atorvastatin
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6
Q

Considerations in statin presscription

A

MOnitor liver function

May cause Rabdo, increased risk by use of fibrates

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7
Q

Contraindicatiosn for Sim astatin

A

Macrolides

INteraction with amlodipine, veramipril, diltiazem

or amlodipine plus statin: PREVASTATIN

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8
Q

Fibrates MOA

A

Activate: PPAR-a to alter liprotein metabolism

  • Promote VLDL breakdown
  • Recude TGs, so can be used with statins when TGs raised
  • Decrease glucose, use in DM
  • Reduce IHD, but not mortality

SE: RHABDO

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9
Q

Cholesterol Absorption inhibitors

A

Ezetimibe

For use on top of statin

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10
Q

Use of Fish oils

A
  • For Hypertriglyceridaemia
  • But INCREASE LDL
  • Eicosapentaenoic acid compeotes with arachidonic acid for COX
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11
Q

Dyslipidaemia management steps

A
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