Drug Interactions 4 Flashcards
1
Q
nACHR
A
Pentameric
2ACh required
Opens for 1ms -> 10^4 Na+ in
2alpha, beta, gamma
2
Q
GABA-A
A
Ionotopic
Pentameric
3
Q
Glycine Receptor
A
2 alpha 2 beta
Chloride
4
Q
Glutamate Receptor
A
Tetrameric (M1, M3, M4)
5
Q
P2X
A
Trimeric
6
Q
Heterologous Desensitisation
A
G protein uncoupling via cAMP/PKA pathway
7
Q
Homologous Desensitisation
A
Ligand -> B2 -> BARK -> B-arresting -> sequestration
8
Q
VG Sodium Channel
A
Tetrameric
M gated -> closed
Inactivation loop -> inactivation
9
Q
Katp channels
A
Closed by ATP
10
Q
Inward Rectifying K channels
A
Spermine polyamide gates
Magnesium block above certain mV
eg. G-protein Activative Kir (GIRK)