Drug Interactions 4 Flashcards

1
Q

nACHR

A

Pentameric
2ACh required
Opens for 1ms -> 10^4 Na+ in
2alpha, beta, gamma

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2
Q

GABA-A

A

Ionotopic

Pentameric

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3
Q

Glycine Receptor

A

2 alpha 2 beta

Chloride

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4
Q

Glutamate Receptor

A

Tetrameric (M1, M3, M4)

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5
Q

P2X

A

Trimeric

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6
Q

Heterologous Desensitisation

A

G protein uncoupling via cAMP/PKA pathway

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7
Q

Homologous Desensitisation

A

Ligand -> B2 -> BARK -> B-arresting -> sequestration

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8
Q

VG Sodium Channel

A

Tetrameric
M gated -> closed
Inactivation loop -> inactivation

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9
Q

Katp channels

A

Closed by ATP

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10
Q

Inward Rectifying K channels

A

Spermine polyamide gates
Magnesium block above certain mV
eg. G-protein Activative Kir (GIRK)

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