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Drug Interactions > Drug Interactions 1: intracellular pathways > Flashcards

Drug Interactions 1: intracellular pathways Flashcards

0
Q

Pertussis Toxin

A

ADP-ribosylation of alpha-i subunit of G proteins.

Prevents activation of alpha-i in response to receptor stimulation thus raising cAMP.

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1
Q

Cholera Toxin

A

ADP-ribosylates alpha-s subunit of G proteins.

This inhibits GTPase activity resulting in sustained activation of adenylyl cyclase and raised cAMP.

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2
Q

Presdnisolone

A

Glucocorticoid agonist

“Preeese, Dennis, go and sniff some glu!”

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3
Q

Spironolactone

A

Mineralocorticoid antagonist
Diuretic

“Spiral away the minerals”

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4
Q

Ethinylestradiol

A

Estrogen agonist

Combined contraceptive pill

“Ethyl likes to straddle girls and boys with high estrogen counts’

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5
Q

Tamoxifen

A

Estrogen antagonist

Used in treatment of HER2 positive breast cancer

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6
Q

Norethisterone

A

Progesterone agonist

Used in combined contraceptive pill

“Go north and you will meet pro-choice peeps”

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7
Q

Tyrphostins

A

TYRrosine PHOSphaTe cascade INhibitors

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Drug Interactions (4 decks)

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