Drug Interactions 3

Question 1

Bay K 8644

Answer 1

Dihydropyridine
Calcium agonist
Opens L type calcium channels in smooth and cardiac muscle cells
Favours mode 2 (macroscopic currents, open for a long time)
Highly lipid soluble

Question 2

Nifedipine

Answer 2

Dihydropyridine
Calcium antagonist
Closes L type calcium channels on smooth + cardiac mm.
Favour mode 0 ( closed) 
Highly lipid soluble
Anti hypertensive

Question 3

Verapamil

Answer 3

Calcium channel blocker
Reduces DHP binding
Use dependent blockade
Antidysrythmic

Question 4

Diltiazem

Answer 4

Calcium channel blocker
Use dependent blockade
Enhances DHP binding
Antidysrythmic

Question 5

Benzilylcholine mustard

Answer 5

Non selective antagonist for muscarinic receptors.

Irreversibly alkylates the receptor.

Unstable cyclised ring breaks and covalently binds to alkylated receptor.