drug induced pigmentary changes

Question 1

What are some of the most common drugs that cause hyperpigmentation?

Answer 1

• antimalarials (hydroxcycloroquine)
• minocycline
• zidovudine
• heavy metals

Question 2

What are some drugs that can cause hypopigmentation?

Answer 2

• tyrosine kinase inhibitors (imatinib- due to inhibition of KIT receptor)
• phenols/catechols (including hydroquinone)
• sulfhydryls (methimazole)
• corticosteroids
• azelaic acid
• arsenic