AGEP

Question 1

90% of AGEP is caused by ______

Answer 1

• Drugs
• other causes: mercury exposure, radio-contrast (like guy you saw on consults), enterovirus

Question 2

What is the time course (after drug administration) and presentation of AGEP?

Answer 2

high fever with numerous non-follicular pustules on erythematous background starting <4 days after drug administration. Rapidly generalizes to involve entire body

• 50% of patients have purpuric or EM-like lesions, mucosal involvement, edema of hands/face, or bullae (these findings help differentiate from pustular psoriasis

Question 3

Most common drugs with AGEP:

Answer 3

• Beta-lactams (cephalosporins+PCNs)
• Macrolides
• Calcium channel blockers
• Antimalarials

Bought More Camera Attachments

(AGEP→Ashfaq)

Question 4

Histopath of AGEP:

Answer 4

• subcorneal and intraepidermal spongiform pustules, prominent superficial dermal edema
• perivascular mixed inflam with eos
• presence of edema and eos, and lack of acanthosis helps to differentiate from psoriasis

Question 5

Tx of AGEP:

Answer 5

Stop drug, supportive therapy, topical CS, antipyretics (patients usually have high fevers)

Question 6

Lab findings in AGEP:

Answer 6

• leukocytosis
• neutrophilia
• hypocalcemia
• renal insufficiency