drug induced hemolytic anemia Flashcards
drug induced HA
pos dat caused by a drug seen as an interference
what are some blood products as drugs
RhIg
IVIg
what is done if there is a drop in bilirubin
hemoglobin is monitored
DAT, BILI, AND LD are montitored
methyldopa HA
antihypertensive drug used in pregnancy
makes autoAb related to does and time resulting in a positive DAT
anemia
why is a methyldopa HA significant
an autoantibody is produced that is serologically indistinguishable from WAIHA
- pan reactions
- specificities
treatment of methyldopa HA
stop drug treatment and switch to safer option
may be put on steroids
significance of penicillin
drug adsorption by IV penicillin
- will bind to rbc
- comples then stimulates an immune response
- IgG antibody classification
lab results of a penicillin
pos DAT
neg Ab screen - not in panel
neg eluate - not a known antibody
quinidine immune complex response
anti-malarial drug
patient will make drug antibody
Ab-Ag complex binds rbc to activate complement causing intravascular hemolysis
immune complex response lab result
pos C3d dat
neg IgG dat
neg Ab screen - drug
neg eluate ( cannot eluate C3d from rbc)
cephalosporins
uses adsorption mechanism that modifies the rbc membrane (sticky membrane)
- caused non specific protein binding: complement, IgG, IgM, IgA
cephalosporin membrane modification lab results
pos DAT
neg Ab screen
neg eluate
