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ESAR 3.4 Exam 1 > Drug-drug Interaction Information > Flashcards

Drug-drug Interaction Information Flashcards

1
Q

Amiodarone DDI

A

Major CYP 2C9 and 3A4 inhibitor

Extremely long half life (40-55 days)

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2
Q

Warfarin - Coumadin DDI

A
  • R-enantiomer major substrate of CYP3A4, 1A2
  • S-enantiomer major substrate of CYP2C9
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3
Q

Digoxin - Lanoxin DDI

A

P-glycoprotein substrate
Diuretics - increase risk of digoxin toxicity (due to potassium depletion)

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4
Q

Phenytoin - Dilantin DDI

A

Major substrate of CYP2C19 & 2C9

Phenytoin induces CYP1A2, 3A4, 2C9, 2C19

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5
Q

Phenobarbital DDI

A

CYP2C19 substrate

Phenobarbital is a CYP1A2, 2C9, 3A4 inducer

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6
Q

Lithium

A
  • ACE-Is, ARBs, diuretics, NSAIDs - increase risk of lithium toxicity; lithium use with NSAIDs is contrandicated
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7
Q

Theophylline DDI

A
  • Major substrate of CYP1A2; cigarette and marijuana smoking may reduce theophylline levels (smoking induces 1A2 enzyme)
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8
Q

Ritonavir DDI

A

major CYP3A4 inhibitor

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9
Q

Cobicistat DDI

A

major CYP3A4 inhibitor

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10
Q

Tacrolimus DDI

A

Tacrolimus is a major CYP3A4 and P-glycoprotein substrate
vaccines

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11
Q

Cyclosporine DDI

A

major CYP3A4 and P-glycoprotein substrate
vaccines
nephrotoxic drugs

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12
Q

Carbamazepine DDI

A

major CYP3A4 substrate and strong CYP3A4 inducer (autodinduction of its own metabolism also present)

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13
Q

Oxycodone/Acetaminophen DDI

A

major CYP3A4 substrate (caution when used with inducers, inhibitors, and substrates); CNS depressants

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14
Q

Codeine + Acetaminophen - Tylenol #2, Tylenol #3 DDI

A

major CYP2D6 substrate
CNS depressants

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15
Q

Hydrocodone/Acetaminophen - Vicodin DDI

A

major CYP3A4 substrate
CNS depressants

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16
Q

Fentanyl - Duragesic DDI

A

major CYP3A4 substrate
CNS depressants

17
Q

Oxycodone - OxyContin DDI

A

major CYP3A4 substrate
CNS depressants

18
Q

Methadone - Dolophine DDI

A

major CYP3A4 and CYP2B6 substrate
QTc prolonging drugs; CNS depressants; MAOIs

19
Q

Buprenorphine DDI

A

major CYP3A4 substrate

20
Q

Buprenorphine/naloxone - Suboxone DDI

A

major CYP3A4 substrate

ESAR 3.4 Exam 1 (11 decks)

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