Drug Dosages

Question 1

Thiopental

Answer 1

induction: 2.5-5mg/kg

Question 2

Methohexital

Answer 2

induction: 1-2mg/kg
rectal (pedes): 25mg/kg
infusion: 50-150mcg/kg/min

Question 3

Midazolam

Answer 3

preop: .02-.04mg/kg
PO: .4-.8mg/kg (admin 30 minutes pre induction)
.2mg/kg IV starts to decrease BP and increase HR. CO not altered
postop sedation: .5-4mg loading dose, 1-7mg/hr gtt
paradoxical vocal cord motion: upper airway obstruction with stridor: .5-1mg

Question 4

diazepam

Answer 4

.1mg/kg

Question 5

Flumazenil

Answer 5

initial dose .2mg IV. further doses of .1mg IV given q1min.

.5-1mg will abolish therapeutic effect

Question 6

propofol

Answer 6

adult dose: 1.5-2.5mcg/kg. decrease this in elderly, increase this in pedes.
IV sedation: 25-100mcg/kg/min infusion
anesthesia maintenance: 100-300mcg/kg/min
antiemetic: 10-15mg IV followed by 10mcg/kg/min infusion
antipruritic: 10mg IV r/t intrathecal opioids, cholestasis
anticonvulsant: 1mg/kg IV

Question 7

etomidate

Answer 7

induction dose: .2-.4mg/kg IV
induction dose up to .3mg/kg results in minimal SE.
>.45mg/kg results in SE.

Question 8

ketamine

Answer 8

adult induction: 1-2.5mg/kg IV
IM: 4-8mg/kg (<10min onset)
10mg/kg PO (10-20min onset)
analgesia at sub anesthetic doses: .2-.5mg/kg (somatic >visceral effects)
.5-1mg/kg prior to surgical incision. may be followed by infusion. has a role in preventing hyperalgesia

Question 9

dexmedetomidine

Answer 9

TIVA: .5-1mcg/kg bolus over 15 minutes
infusion: .2-.7mcg/kg/hr (up to 24 hours)
4mcg bolus for pain, up to 16mcg
.5-2mcg/kg for pain

Question 10

scolpalamine

Answer 10

preop: .3-.5mg IV/IM

Question 11

physostigmine

Answer 11

15-60mcg/kg IV and repeat as required

Question 12

codeine

Answer 12

15mg oral cough suppressant
60mg=650mg ASA
120mg IM=10mg morphine

Question 13

meperidine

Answer 13

12.5mg IV

Question 14

fentanyl

Answer 14

1-3mcg/kg prior to induction
1-3mcg/kg intraop for analgesia
50-150mcg/kg for surgical anesthesia
trans mucosal pedes, give 45 min prior to induction
transdermal: for ca, lasts x3d or give 24h prior to operation.

Question 15

sufentanil

Answer 15

for analgesia: .1-.4mcg/kg

Question 16

alfentanil

Answer 16

15mcg/kg IV blunts stimulation of laryngoscopy
30mcg/kg IV catecholamine response to noxious stimulation
150-300mcg/kg IV produces unconsciousness (induction).
in combination with inhaled anesthetic, 15-150mcg/kg/hr

Question 17

naloxone

Answer 17

1-4mcg/kg IV

5mcg/kg/hour can fix depression of ventilation without affecting analgesia

Question 18

nalmefene

Answer 18

15-25mcg IV until effects achieved (max dose 1mcg/kg)

Question 19

acetaminophen

Answer 19

PO: 325-650mg q4-6h
Ofrimev: 1g q6h
don’t exceed 4g/24h or 2g/24h for alcoholics

Question 20

gabapentin

Answer 20

preop 1200mg 1-2h before surgery

600mg q8h x 14 days

Question 21

toradol (ketorlac)

Answer 21

15mg IV or IM q6h

Question 22

celebrex (celecoxib)

Answer 22

400mg PO preop, 200mg BID x5d postop

Question 23

lidocaine

Answer 23

1.5mg/kg bolus IBW

1-2mg/kg/hr infusion

Question 24

magnesium sulfate

Answer 24

30-50mg/kg bolus

10mg/kg/h infusion

Question 25

capsaicin

Answer 25

avail OTC in .025, .075, .25% creams or transdermal patches

Question 26

succinylcholine

Answer 26

tracheal intubation 1mg/kg IBW

Question 27

cisatricurium

Answer 27

intubating dose .1mg/kg

Question 28

mivacurium

Answer 28

.15mg/kg

Question 29

pancuronium

Answer 29

.08mg/kg

Question 30

vecuronium

Answer 30

.1mg/kg

Question 31

rocuronium

Answer 31

.6mg/kg

Question 32

neostigmine

Answer 32

40-80mcg/kg, max dose 6mg

Question 33

edrophonium

Answer 33

1-1.5mg/kg

Question 34

glycoporrolate

Answer 34

5-10mcg/kg

200mcg for every 1mg neostigmine

Question 35

atropine

Answer 35

5-10mcg/kg, .01mg/kg

Question 36

sugammadex

Answer 36

TOF >2, 2mg/kg
TOF 1-2, 4mg/kg
TOF 0, 8-16mg/kg

Question 37

nalbuphine

Answer 37

30mg IV

Question 38

remifentanil

Answer 38

1mcg/kg bolus followed by infusion of .05 to .2mcg/kg/min for 10 min prior to induction agent

analgesia: .05-.2mcg/kg/min for infusion
sedation: .05-.2mcg/kg/min in combination with midazolam 2mg