4 Written Questions for Exam 3

Question 1

Desirable properties of induction agent

Answer 1

1. rapid onset and smooth recovery
2. favorable PK/pharmaceutics
3. no toxicity or histamine release
4. antiemetic actions
5. analgesia
6. minimal cardiac and respiratory depression
7. antiemetic actions

Question 2

PK

Answer 2

what the body does to the drug
absorption, distribution, metabolism, excretion
includes protein binding, ionization, lipid solubility, plasma distribution curve

Question 3

PD

Answer 3

what the drug does to the body. includes measuring potency, efficacy, dose response curve

Question 4

least to most ionized phenylpiperdine

Answer 4

alfentanil 10% ionized
remifentanil 42% ionized
sufentanil 80% ionized
fentanyl 90% ionized

Question 5

Vd for phenylpiperdines

Answer 5

1. fent (4)
2. sufent (2)
3. alfent (.6)
4. remifent (.42)

Question 6

Pka of phenylpiperdines

Answer 6

1. fent 8.4
2. sufent
3. remifent
4. alfent 6.5

Question 7

Dose for phenylpiperdines (potency)

Answer 7

1. sufent .1-.4mcg/kg
2. fent 1-3mcg/kg
3. remifent 1-3mcg/kg
4. alfent 15mcg/kg