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Pharmacology > Drug Discovery > Flashcards

Drug Discovery Flashcards

1
Q

Traditional meds for beart ailments

A

Foxglove: digitalis glycoside

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2
Q

Traditional med used as NM relaxant

A

Curare: tubocurarine

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3
Q

Traditional meds for pain relief

A

Opium poppy: opiates

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4
Q

Traditional meds for diabetes now used in cancer therapy

A

Periwinkle: vincas

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5
Q

Med accidentally discovered for mania

A

Lithium

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6
Q

Med accidentally discovered for psychosis

A

Chlorpromazine

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7
Q

Med accidentally discovered for bacterial infection

A

Penicillin

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8
Q

Med accidentally discovered for penile dysfunctio

A

Silldanefil

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9
Q

Among Filipinos, 50% of lung cancer is due to

A

EGFR mutations

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10
Q

Examples of EGFR tyrosine kinase inhibitors

A

Erlotinib
Gefitinib
Afatinib
Osimertinib

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11
Q

Examples of EGFR tyrosine kinase inhibitors

A

Erlotinib
Gefitinib
Afatinib
Osimertinib

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12
Q

Examples of Gs receptors

A

Beta receptors
5-HT
H1

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13
Q

Examples of Gi

A

Presynaptic a2, 5-HT1A

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14
Q

Examples of Gq

A

a1
Postsynaptic a2
M3

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15
Q

Examples of RTKs

A

Insulin R.
EGFR
HER2

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16
Q

Ex. of catalytic receptor

A

Interleukin receptors

17
Q

ACE inhibitors

A

Enalapril

Captopril

18
Q

Na+ gated channels are inhibted by

A

Class I anti-arrhythmics
Local anesthetics
Anticonvulsants

19
Q

K+ channels are inhibited by

A

Class III anti-arrhythmics

20
Q

Ca2+ channels are inhibited by

A

Class IV anti-arrhythmics

21
Q

Nicotinic receptors stimulated by

A

ACh

Auccinylcholine

22
Q

Nictonic receptors inhibited by

A

Non-depolarizing NM blockers
Atracurium
Pancurium

23
Q

GABA A receptor stimulated by

A

Benzodiazepines (diazepam, midazolam)
Barbituratea
gaba

24
Q

Na/K atpase inhibitor

A

Digoxin

25
Q

H/K atpase inhibitors

A

PPIs (-prazoles)

26
Q

Colchicine

A

Drug for gout

27
Q

Mitotic spindle inhibitors

A

Vincas, taxanes

28
Q

Dimercaprol

A

As, Hg, Au, Pb overdose

29
Q

Penicillamine used for

A

Copper overdose

30
Q

Desferoxamine used for

A

Fe overdose

31
Q

Example of irreversible drug

A

Clopidogrel - antiplatelet aggregant

Pharmacology (3 decks)

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