drug development

Question 1

define draggability

Answer 1

Druggability: the ability of a protein target to bind small molecules with high affinity (sometimes called ligandability).

Question 2

give examples of sources drugs are developed from

Answer 2

plants eg. digoxin from digitalis

inorganic elements

organic molecules

bacteria, fungi, moulds

stereoisomers

animals

gene therapy

Question 3

define stereoisomers

Answer 3

have the same molecule formula and sequence of bonded atoms, but differ in the 3D orientations of their atoms in space

Question 4

what are recombinant proteins?

Answer 4

The strategy for expressing recombinant protein involves transfecting a particular cell with DNA vector containing the template of recombinant DNA. The cells containing the template are then cultured, so that they can transcribe and translate the protein of interest.
produce proteins within bacteria → purify proteins

Question 5

what is gene therapy

Answer 5

Replacing or inactivating a mutated gene that causes disease with a healthy copy of the gene

Gene therapy consists of a recombinant nucleic acid used in or administered to a human being with a view to regulating, replacing, adding or deleting a genetic sequence

Question 6

define rational drug design

Answer 6

The process of finding new medications based on the knowledge of a biological target

Question 7

what is drug repurposing

Answer 7

Technique whereby existing drugs are used to treat emerging and challenging diseases