Drug detection and testing Flashcards

1
Q

why? (5)

A
  • treatment
  • safety
  • anti-doping
  • law enforcement
  • research
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2
Q

biological samples (5)

A
  • blood
  • breath
  • urine
  • saliva
  • hair
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3
Q

what to measure? (3)

A
  • identification (screening)
  • measure levels
  • known vs unknown
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4
Q

Alc det on the go(4)

A
  • Breathalyzer
  • 0.08% BAC (estimated)
  • Chemical colour test with sulphuric acid, silver nitrate and potassium dichromate
  • Colour change – electric current in meter

(prone to error)

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5
Q

alc det - follow up tests (3)

A
  • Intoxilyzer – infrared
    spectroscopy
  • IR beam in wavelengths for chemical bonds in
    ethanol
  • IR absorption –electrical signal

(but a lot of more alc metabolised by now - so look for metabolites)

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6
Q

Solid tests – lateral flow tests - easy to use (5)

A

Immunoassays : antibodies already present

  • Cocaine
  • Ketamine
  • THC
  • Methamphetamine
  • Benzodiazepines

one chemical/ test

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7
Q

solid test benefits (7)

A
  • Simple
  • Rapid
  • Visual interpretation
  • On-site detection
  • Kit completes with swab for sample collection, buffer solutions, bottle for mixing compound and
    test cartridge
  • Some have Home office approval – police, customs
  • Sensitivity ? Detection times ? Specificity?
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8
Q

Urine test strips - how do you use it?

A
  1. Allow the test to absorb the urine for about 10-15 seconds.
  2. Remove the test from the urine and replace the test cap.
  3. Lay the test on a clean flat surface while the test lines develop.
  4. You can read negative results as soon as they appear but positive results must be read at least 5 minutes after removing from urine
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9
Q

urine uses e.g.’s (7)

A

Example tests: may have more than one
* Cocaine
* Benzodiazepines
* Methamphetamines
* Amphetamines
* Cannabis
* Opioids
* Methadrone

yes and no answer

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10
Q

What does a positive/ negative result mean?

A

+ = present
- = not present

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11
Q

What to consider when looking at results? (4)

A
  • what is being tested? (many chemicals i.e. THC)
  • what is the detection limit? (need a lot of drug to show result?)
  • When was the drug taken (and how much)? - metabolism, how much and when it was taken
  • How to confirm the initial tests? (ir)
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12
Q

Home testing kits

A

ecstasy pill testing - is very easy to do (just need to identify the right colour) - just need to keep an eye out for colours but also individual diff’s - colours (dark or light)

e.g.
* MDMA
* Methamphetamine
* Morphine

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13
Q

Multiple chemicals in tablets - some don’t show up in home testing (4)

A
  • PMA in pill doesn’t show up in home testing
  • PMA: 4 methoxyamphetamine
    = deaths from this for many and many didn’t show up in tests
  • Mandelin reagent: ammonium vanadate in
    concentrated sulphuric acid
  • Mecke reagent: selenous acid in in concentrated
    sulphuric acid
  • “qualitative” test
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14
Q

ACMD report on powdered cocaine - onitoring e.g. (2015) (3)

A
  • Increased availability of cheap, low purity powdered cocaine
  • Cocaine (including crack) was involved in, but not necessarily the cause of, 234 of 3,521deaths in England,
    Scotland and Wales in 2013
  • More than 50 cutting agents have been identified, including some that can cause serious medical harm
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15
Q

more accurate testing: GC benefits (5)

A
  • Laboratory test
  • Reliable
  • Sensitive
  • Screening of substances
  • Quantitative
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16
Q

more accurate testing: IS benefits (6)

A
  • Unambiguous identification
  • Reliable
  • Rapid
  • Extensive drug library needed inc IR spectra of legal highs,
    pharmaceutical compounds and
    common chemicals
  • No sample preparation
  • Portable – use outside
    laboratories ?
17
Q

Databases usage + benefits (5)

A

of IR and results (not based on solid tests)
= less tedious
= easier to identify compounds

(TICTAC in SGUL)
-shape
-colour
-appearance
-nicknames

  • for public
  • for law enforcement
  • for scientists
18
Q

database keeps up with makers + users - cycle

A

cycle:
1) detection
2) blanket ban
3) new substances invented

  • Designer drugs: modified structures of existing substances
  • Failed pharmaceuticals or research compounds
  • Each country is different
  • EMCDDA, UNODC
19
Q

Where do we do the detective work? (8)

A
  • Internet / headshops
  • Systematic screening for new compounds
  • Monitor effects of new legislations
  • Amnesty bins from clubs or festivals
  • Search before entry, anything left in sealed container
  • Police and Border Agency
  • Drug testing following arrest
  • Seizures (inc. unclaimed parcels)
  • Hospital admissions
  • Questionnaires (brand names only)
  • Waste
  • Pooled urine (no female samples)
  • Sewage
20
Q

Summary (5)

A
  • Analytical techniques
  • Qualitative vs quantitative
  • Sample types
  • Active vs inactive ingredients
  • Monitoring emerging drug use