Animal Models Of Addiction Flashcards

1
Q

What things should you consider when choosing an animal model? (4)

A

Do you just want to model a condition?

Are you interested in only certain symptoms/pathologies?

Are you interested in treatments?

Do you want to examine the disease process?

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2
Q

What are the 3 validity types of Animal Models?

A

Construct, Face + Predicative

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3
Q

Define Construct Validity

A

The model has a sound theoretical rationale

(neurobiological or psychological mechanisms, aetiology)

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4
Q

Define Face Validity

A

Phenomenological similarity between the model and the
disorder being modelled (symptoms)

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5
Q

Define Predicative Validity

A

Manipulations known to influence the pathological state
should have similar effects in the model (drugs)

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6
Q

A chronic relapsing disorder characterised
by: (3)

A
  1. Compulsion to seek and take the drug
  2. Loss of control in limiting intake
  3. Emergence of a negative emotional state (dysphoria, anxiety, irritability)
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7
Q

What can we model?
The different stages of addiction (12)

A

(1) substance abuse – drug taking
(2) Drug seeking behaviour
(3) Drug addiction/drug dependence
(4) increase in tolerance/sensitisation
(5) acute withdrawal symptoms
(6) chronic (long-term) withdrawal
(7) Compulsion to use
(8) relapse
(9) context dependency
(10) genetic models – KO mice
(11) Neurochemical models?
(12) other models?

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