Animal Models Of Addiction Flashcards
What things should you consider when choosing an animal model? (4)
Do you just want to model a condition?
Are you interested in only certain symptoms/pathologies?
Are you interested in treatments?
Do you want to examine the disease process?
What are the 3 validity types of Animal Models?
Construct, Face + Predicative
Define Construct Validity
The model has a sound theoretical rationale
(neurobiological or psychological mechanisms, aetiology)
Define Face Validity
Phenomenological similarity between the model and the
disorder being modelled (symptoms)
Define Predicative Validity
Manipulations known to influence the pathological state
should have similar effects in the model (drugs)
A chronic relapsing disorder characterised
by: (3)
- Compulsion to seek and take the drug
- Loss of control in limiting intake
- Emergence of a negative emotional state (dysphoria, anxiety, irritability)
What can we model?
The different stages of addiction (12)
(1) substance abuse – drug taking
(2) Drug seeking behaviour
(3) Drug addiction/drug dependence
(4) increase in tolerance/sensitisation
(5) acute withdrawal symptoms
(6) chronic (long-term) withdrawal
(7) Compulsion to use
(8) relapse
(9) context dependency
(10) genetic models – KO mice
(11) Neurochemical models?
(12) other models?