Drug contraindications Flashcards
Aortic stenosis containdicated drugs
Anything that reduces peripheral afterload as this will reduce coronary perfusion pressure while the heart still has a fixed afterload (the stenosis) to overcome.
ACE-I
GTN
CCB- Dihydro
Tetracyclins cant be used in children under the age of
12
Quinolones cant be used with this drug because it increases the risk of tendon rupture
steroids
When tazocin cant be used this is used instead in cases of neutropenic sepsis or severe pneumonia that’s not responding
meropenem
If the patient has renal impairment and you are treating a UTI this drug won’t work
Trimethoprim as it increases creatinine and so competes with it and wont get into the urine
Opioids and Benzos
Not a good idea for COPD and liver disease
- respiratory depression –> T2RF
- liver disease - not metabolised –> hepatic encephalopathy
Which laxatives cant you give to bowel obstruction?
Which should you avoid in children and the elderly and why?
- Osmotic and stimulant
- Diet changes and isphagula hulk/bulk forming because they need to drink lots of water with it and this is unlikely to occur, these patients are best started on an osmotic (or osmotic and stimulant in elderly/adults)
Diclofenac or naproxen has more contraindications?
Diclofenac
- risk of MI (uncommon)
- contraindicated in heart failure, and loads more
Triptans and what drug should be avoided?
SSRIs
SSRIs and what drug should be avoided?
Warfarin or heparin. Start patient on amytriptylline instead
Omeprazole or lansoprazole more interactions?
Omeprazole. omeprazole reduces the effectivenesss of clopidogrel
Trastuzumab cannot be used, if the patient has a history of
cardiovascular disease, as it can cause weakening of the heart muscle (cardiomyopathy) or heart failure. similar to pioglitazones
rituximab which infection do you have to screen for?
hepatititis B
because - In chronic Hepatitis B (HBV) infection, the virus can remain in a latent or inactive state within the liver, primarily in the form of covalently closed circular DNA (cccDNA) within hepatocytes.
B cells contribute to the control of HBV infection through the production of neutralizing antibodies against viral antigens (e.g., HBsAg) that help prevent reinfection of hepatocytes by circulating virus particles.
Latent HBV infection can be maintained if B cells generate antibodies at a level sufficient to keep the virus in check without completely clearing it, partly due to the virus’s ability to evade immune detection within infected cells.
Regulatory B cells (Bregs) might also contribute by modulating the immune response, limiting excessive inflammation and helping to maintain a balance where the virus persists in a low-profile latent state, avoiding full activation or complete elimination.
rituximab is an anti-lymphocyte monoclonal antibody that cause lysis of B lymphocytes.
nsaids. which are contraindicated in heart failure and why?
nsaids
- why diclofenic is bad for heart failure and all NSAIDS in general is because of their action on COX2 - usually COX2 increases the GFR - increasing water and sodium loss. But when you inhibit this more renin is released and more water and sodium are reasborbed. But Diclofenic is the strongest for this, and also therefore has more vasoconstrictive effects hence why its association with stroke and thrombosis (as the lumen narrows are atheromas are more likely to break off)
- Naproxen is generally considered safer than diclofenac becauseit has a lower risk of cardiovascular events and gastrointestinal (GI) issues as it has less effect on COX2.
vancomycin and thiazides?
theyre okay.
caution furosemide and vancomycin
pneumonia is a common adverse effect of Trelegy Ellipta®inhaler, which results from the fluticasone component. Common infections include lower and upper respiratory tract infections, bronchitis, pharyngitis, rhinitis, sinusitis, nasopharyngitis and urinary tract infection as well as influenza and candidiasis of the mouth and throat.This is therefore the most likely adverse effect.These adverse effects are commonin patients takingTrelegy Ellipta®for the treatment ofCOPD. Inhaled corticosteroids should only be continued for the treatment of COPD where there is clear evidence of benefit. If no benefit is seen after a trial of inhaled corticosteroid it should be stopped.
