Drug Addiction Flashcards
Drug addiction
Chronic brain disorder
Compulsive drug seeking
Inability to stop using
Dependence on drug
Drug addiction is a disease that effects the _ system
Reward
Makes it hard to resist intense urges to take drugs
What is it called if there is a risk of return of a condition after treatment
Relapsing
How does conditioning relate to addiction?
People and places can become stimuli that make the addict feel compelled to use
Reinforcing
Objective
Something is reinforcing when an animal will perform a behaviour in order to obtain that stimulus.
Rewarding
Subjective
Often linked to euphoria which is a feeling of great happiness or well-being
Rewarding substances can lead to addiction
Psychological dependence
Craving
Compulsive drug use
Loss of control over intake
“addiction”
Physical dependence
When stopping a drug causes a withdrawal symptom
Tolerance
When continued use of a drug results in the need for increasing doses for equivalent effect
The cycle of addiction
Binge/intoxication –>
–> Withdrawal/negative effect –>
–> Preoccupation/anticipation –>
–> Binge/intoxication
Areas involved with binge/intoxication
Dorsal striatum
Ventral Tegmental Area
Cerebellum
Areas involved with withdrawal/negative effect
Basolateral amygdala (BLA)
Central amygdala (CeA)
Areas involved with preoccupation/anticipation
Prefrontal cortex (PFC)
Hippocampus
Which area did rats stimulate using ICSS?
Mesolimbic pathway
How much would rats stimulate the mesolimbic pathway?
Until death
