drug actions

Question 1

Name the transporter blocked by loop diuretics? Where is this located? When is it contraindicated?

Answer 1

Na+/K+/2Cl- cotransporter
Ascending limb of the loop of Henle
hypovolaemia, dehydration, gout, hypokalaemia/hyponatraemia

Question 2

What do thiazide diuretics block? Where is this located? name four thiazide/thiazide like diuretics

Answer 2

Na+/Cl- transporters of the distal convoluted tubule

Bendroflumethiazide, indapamide, metolazone, chlortalidone

Question 3

1. Name the two potassium sparing thiazides that block Na+ channels in the collecting duct
2. What is the action of spironolactone and eplerenone?

Answer 3

1. Amiloride and triamterene

2. Aldosterone receptor blockers

Question 4

Name an osmotic diuretic and explain their action

Answer 4

Mannitol, act by increasing the osmolarity of the filtrate thus increasing water loss