Drug Abuse Flashcards
What are the pharmacological methods of drug treatment?
-Agonist substitution
-Partial Agnonist Substitution
-Antagonists
-Withdrawal maintenance
-Mesolimbic DA regulation
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Partial agonist subsititution
-Provide a level of receptor stimulation that prevents craving, but does not induce abuse
-Use opiates such as buprenorphine (Butrans) has longer half life than methadone
The “Rat Park” experiments, by Bruce Alexander, demonstrated that addiction rates are powerfully determined by
Social and environmental factors
Drug vaccines, such as NicVax, are probably most effective at
Preventing addiction
Relapse is most likely induced by all of the following EXCEPT
Decreased sensitivity of DA receptors
The reason antagonist administration strategies are often unsuccessful is due to
Patient non-compliance
Stress impacts addiction in all of the following ways EXCEPT:
Stress increases the efficacy of addictive drugs
The mesolimbic pathway is made up of neurons that produce
Dopamine
The drugs used in agonist substitution protocols tend be chosen because they
Have longer half-lives
The use of Chantix to help people stop using nicotine is an example of what kind of pharmaceutical approach?
Partial agonist substitution
Administration of Methadone to heroin addicts is an example of
Agonist substitution
Using naltrexone to treat alcohol abuse is an example of which pharmaceutical approach?
Antagonist administration
The following are all advantages of the partial-agonist substitution pharmacological approach EXCEPT:
Blocks pleasurable effects of the drug
The use of clonidine to treat alcohol/opiate addiction is an example of which pharmaceutical treatment strategy?
Withdrawal maintenance
The mesolimbic pathways begin in the VTA and terminates in the
Nucleus accumbens, amygdala, and prefrontal cortex
