Cannabinoids Flashcards
What are the pharmacokinetics of cannabinoids?
Cannabinoids are lipid soluble and concentrated in the fat
What are the pharmacodynamics of cannabinoids?
-There are 2 types of cannabinoid receptors
-CB1 which is in the central nervous system and is one of the most populous receptors in the brain
-CB2 which is in the periphery
What are the CNS effects of cannabis?
-Cannabis affects the CNS and impairs reaction time where 2-5 mg/ml in the plasma is associated with increased auto accidents
-You may not feel the effects
What is an important symptom of withdrawal?
-Irritability
What is the toxicity for cannabinoids?
-An LD50 is not known for humans
What is rimonabant?
-A cannabinoid also called Accomplia and the first in class of therapeutic agents called cannabinoid 1-receptor blockers
-Primary indication is the adjunct to diet and exercise in treatment of obese patients with associated risk factors such as type 2 diabetes and dyslipidemia
-Primary indication is also to treat marijuana dependence
What is the pharmacodynamics of rimonabant?
-It is the inverse agonist for cannabinoid receptor CB-1
-Reduces appetite
What is Nabilone?
-A synthetic cannabinoid used primarily as an antiemetic for nausea and vomiting caused by chemotherapy
-Also mimics tetrahydrocannabinol (THC), the primary psychoactive compound found in cannabis
-Produces a multitude of side effects and is a very strong drug
-Has a high risk for dependence or addiction
-Last resort medication when benefits outweigh the risks
-Take regular doses for best results
-Do not mix with contraindicated drug interactions because it can produce psychomimetic symptoms
What is cannabidiol?
-CBD or Epidiolex/Sativex is a nonpsychoactive phytocannabinoid that contains antiepileptic properties when used to treat serious and rare forms of seizures and sclerosis which is the only FDA approved use
-Produces separate effects from cannabis and THC
-Safer than other cannabinoids and has no scientific evidence of tolerance of addiction
What is drobinol?
-A man-made version of THC that is effective for treating HIV/AIDs induced anorexia and weight loss, and for CINV patients who fail to respond to conventional antiemetics
-Not a 1st line treatment due to its psychoactive and CNS taxing effects
In the US marijuana is currently listed under which DEA schedule?
I
In California marijuana was legalized for non-medical use in
2016
The route of administration of Sativex is
Oral mucosal spray
Which of the following is NOT a primary indication of dronabinol?
Anxiety
The major psychoactive ingredient in the marijuana plant is:
delta-9-tetrahydrocannabinol (THC)
Nabiximols is a
non-synthetic cannabinoid agonist
Hashish and marijuana differ mainly in their
Potency
A primary indication for cannabidiol is
Seizure reduction
Epidiolex is a ______ at CB receptors
Partial agonist
Which of the following is NOT an off-label use for Epidiolex?
Weight loss
THC can take up to 5 weeks to be completely excreted from the body because
It is highly lipid soluble
The main ROA for dronabinol is
Oral
The most ubiquitous receptors in the brain appear to be those responsive to
cannabinoids
Marinol is a
synthetic cannabinoid agonist
