Cannabinoids Flashcards
What are the pharmacokinetics of cannabinoids?
Cannabinoids are lipid soluble and concentrated in the fat
What are the pharmacodynamics of cannabinoids?
-There are 2 types of cannabinoid receptors
-CB1 which is in the central nervous system and is one of the most populous receptors in the brain
-CB2 which is in the periphery
What are the CNS effects of cannabis?
-Cannabis affects the CNS and impairs reaction time where 2-5 mg/ml in the plasma is associated with increased auto accidents
-You may not feel the effects
What is an important symptom of withdrawal?
-Irritability
What is the toxicity for cannabinoids?
-An LD50 is not known for humans
What is rimonabant?
-A cannabinoid also called Accomplia and the first in class of therapeutic agents called cannabinoid 1-receptor blockers
-Primary indication is the adjunct to diet and exercise in treatment of obese patients with associated risk factors such as type 2 diabetes and dyslipidemia
-Primary indication is also to treat marijuana dependence
What is the pharmacodynamics of rimonabant?
-It is the inverse agonist for cannabinoid receptor CB-1
-Reduces appetite
What is Nabilone?
-A synthetic cannabinoid used primarily as an antiemetic for nausea and vomiting caused by chemotherapy
-Also mimics tetrahydrocannabinol (THC), the primary psychoactive compound found in cannabis
-Produces a multitude of side effects and is a very strong drug
-Has a high risk for dependence or addiction
-Last resort medication when benefits outweigh the risks
-Take regular doses for best results
-Do not mix with contraindicated drug interactions because it can produce psychomimetic symptoms
What is cannabidiol?
-CBD or Epidiolex/Sativex is a nonpsychoactive phytocannabinoid that contains antiepileptic properties when used to treat serious and rare forms of seizures and sclerosis which is the only FDA approved use
-Produces separate effects from cannabis and THC
-Safer than other cannabinoids and has no scientific evidence of tolerance of addiction
What is drobinol?
-A man-made version of THC that is effective for treating HIV/AIDs induced anorexia and weight loss, and for CINV patients who fail to respond to conventional antiemetics
-Not a 1st line treatment due to its psychoactive and CNS taxing effects
In the US marijuana is currently listed under which DEA schedule?
I
In California marijuana was legalized for non-medical use in
2016
The route of administration of Sativex is
Oral mucosal spray
Which of the following is NOT a primary indication of dronabinol?
Anxiety
The major psychoactive ingredient in the marijuana plant is:
delta-9-tetrahydrocannabinol (THC)
