Droperidol - Updated 2023.09.01

Question 1

Adult behavioral emergency droperidol

Answer 1

Droperidol 2.5 to 5 mg IV/IO
OR
5 to 10 mg IM

Question 2

Droperidol class of medication

Answer 2

Dopamine antagonist:
- anesthesia adjunct
- Antiemetic
- Central Nervous System Agent
- Dopamine Antagonist

Question 3

How does Droperidol affect the CV system?

Answer 3

Partial alpha-adrenergic BLOCKade. As a result, thi.s produces prolonged QT, cardiac arrest, , VTach, Torsades, or hypotension

Question 4

Contraindications for droperidol

Answer 4

Long QT syndrome;
Known allergy

Question 5

How does Droperidol affect the nervous system?

Answer 5

Blocks dopamine, potentially leading to coma, dizziness, dyskinesia, and somnolence

Question 6

How does Droperidol affect the respiratory system?

Answer 6

Bronchospasm, laryngeal spasm, pulmonary embolism, respiratory depression, respiratory distress

Question 7

Droperidol acts specifically on what receptor(s)?

Answer 7

Droperidol acts upon the alpha-adrenergic receptors of the CNS.

Question 8

Describe the locations of alpha 1 and 2 receptors.

Answer 8

a-1 are found in vascular smooth m., a-2 in the brain where the moderate sympathetic outflow.

Question 9

Explain alpha-1 receptor agonism

Answer 9

The toxicity of alpha-1 blockers and alpha-2 agonists is an unopposed parasympathetic activity, with bradycardia, hypotension, miosis, and sedation. Observation is sufficient in asymptomatic patients. Supportive care is necessary for symptomatic patients.

Question 10

Explain alpha-2 receptor agonism.

Answer 10

The toxicity of alpha-1 blockers and alpha-2 agonists is an unopposed parasympathetic activity, with bradycardia, hypotension, miosis, and sedation. Observation is sufficient in asymptomatic patients. Supportive care is necessary for symptomatic patients.

Question 11

Adrenergic receptors bind ______.

Answer 11

Epi and norepi (think “adrenaline receptors”). As a result, they increase HR, BP, RR, etc.