Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neurology > DROGA LIST > Flashcards

DROGA LIST Flashcards

1
Q

Lamotrigine (Lamictal)

A

Moa: Nat+ inactivation
Indicated: focal partial seizure more so adjunct therapy, to of Lennox G seizures, Bipolar trigeminal neuralgia .
Dosing: Titrate up 4 weeks to reduce risk of lamictal rash can be fatal.
Lamictal Rash risk increase with use of VPA.
Stop Lamictal.
Metabolizes UGT, and induces UGT.
CNS ADE: dizziness, diplopia, HA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Phenobarbital

A

MOA: GABA A- CL- open
Indications: sedation, epilepsy- focal and generalize.
Class 4 Scheduled drug
CI: Preg Cat D, Resp Dz, Liver Dz
Monitor: over sedation, osteoporosis CBC, PB.
1st line in neonate seizures.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ethosuximide

A

MOA:CA+ Blocks
MC: Tx fro absent seizures in children
ADE: GI upset, CNS depression
Generally well tolerated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Primidone

A

Primidone parent drug- children = phenytoin and PB
Formulation: Oral use
Indication: antiseizure mostly used for essential tremor
Takes 20 days for PB to build up check levels of Pb and primidone
Order: CBC at baseline then 6 mo
Watch toxicity in elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Phenytoin

A 
Therapeutic range 300-400mg
MOA: Blocks NA+ channel inhibits repetitive AP
Oral Phenytoin= prevent seizures 
IV= for active clinic tonic seizures 
IV given with antifreeze
Loading dose 1 gram in 20 min
Anything over 40-50 mg per 1 min increases risk for vascular and derm rxn 
IV= purple glove sx
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Fosphenytoin

A

IV formulation more soluble with phosphate group
No need for antifreeze
Faster infusion of 7 min per 1 gram but parent drug so still takes 42 min to work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Major MOA CA2+

A

Gabapentin, Ethoxsumide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Major MOA: NA+

A

Phenytoin, carbamazepine, lamotrigine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Major MOA GABA:

A

Phenobarbital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Gabapentin (neurontin)

A

Indications: adjunct to seizures, post hepatic neuralgia
MOA: Blocks CA+ reentry
ADE: Sedation, dizziness
Check Kidney function
Dose: slow titrate up work up to 300 mg TID.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pregabalin (Lyrica)

A

Schedule 5 drug
Indication: partial epilepsy, dm neuropathy, fibromyalgia pain, post herpatic pain
More potent and better absorbed than gabapentin
ADE: dizziness, euphoria, blurred vision
Take regularly check kidney function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drugs that give rashes that are not nice

A

Lamotrigine
Carbamazepine
Oxcarbamazepine
Phenytoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Enzyme inducers plus hormonal birth control ?

A

Lessens efficacy of BC and can cause pregnancy abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Enzyme inducing drugs

A

Phenytoin hepatic enzyme inducer and saturable metabolism
Carbamazepine enzyme inducer and own metabolism inducer
Phenobarbital enzyme inducer and long 1/2 life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Valproic acid enzyme

A

Enzyme inhibitor UGT and aspirin kicks this drug off

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Valproic acid displacement

A

Valproic acid can be displaced by aspirin risk for toxicity increases.Total vpa goes up in linear fashion but active goes up exponentially.

17
Q

Carbamazepine

A

MOA:NA+ channel blocker
Self CYP 34A inducer- 6wks fixed dose may need to increase dose.
Toxic metabolite: epoxide
Black box warning: aplastic anemia, agranulocytosis
ADE: Hyponatremia, severe derm rash, psychosis.
CI: SSRI, SMRI, TCA, SNR, BC, Cardiovascular drugs, Preg D
Test: HLA-B ALLE

18
Q

Oxcarbazepine

A

Relative to carbamazepine: 1.5 less of the dose needed to be effective
Same ADE, but less severe.
Indication: only for focal epilepsy.
ADE: MORE HYPONATREMIA

19
Q

Eslicarbazepine

A

Similar to carbamazepine and oxcarbazepine
Advantage: daily dosing can be split and crushed, approved as mono therapy
Disadvantage: only FDA for seizure $$$$

20
Q

Clonazepam

A 
Indication: maintenance seizure 
Formulation:Oral regular daily therapy long 1/2 life 
Few drugs interactions
Therapeutic range 
Less tolerance
21
Q

Lorazepam

A

Indication: Maintenece seizure
Formulation = long term oral use for maintenance seizures
IV Formulation: for status epilepticus
1ST line ED seizure

22
Q

Clobazepam

A

Indication: refractory seizure less tolerance with this drug

23
Q

Diazepam

A

Formulations: IV, rectal gel and

24
Q

Midazolam

A

Off label use for rescue drug in seizure

IM- NASAL formulation

25
Q

Benzodiazepines ADE

A

Dependence, tolerance, withdrawal, sedation

26
Q

Acetazolamide

A

Indication: adjunct therapy for seizure control especially refractory seizures
CI: DO NOT USE WHILE ON KETO DIET INCREASE RISK OF ACIDOSIS

27
Q

Valproate VPA (divalproate)

A

Divalproate- less GI upset
Effective against many seizures, bipolar disorder and migraine prophylaxis
MOA: blocks NA+
Formulations: ER. DR. IR. Liquid, sprinkle
Avoid: pregnancy, osteoporosis
No risk for sedation, dependence, tolerance
BBW: LIVER TOXICITY
CHECK LFT after 3-4 days of initial dose

Neurology (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions