DPD

Question 1

SE of metformin, Sulphonyureas, TZDS?

Answer 1

1. GI upset
2. hypog
3. fluid retention, MI?, osteoporosis?

Question 2

Basal insulin drugs (3)

Answer 2

1 insulatard – Added protein

2. glaringe -AA change
3. detemir -FFA

Question 3

Bolus insulin drugs (3)

Answer 3

1. Humalog
2. Novorapid
3. Actrapid

Question 4

Insulin SEs (3)

Answer 4

1. Weight gain
2. Hypos
3. risk of losing driving license if HGV

Question 5

SGLT2 MOA

Answer 5

inhibit SGLT2 in kidneys –> increased renal glucose excretion

Question 6

SGLT2 SEs (2)

Answer 6

1. hypoglycaemia

2. Urogenital infections (balanitis, candidiasis)

Question 7

Clinical features of diabetic nephropathy (3)

Answer 7

1. Progressive proteinuria
2. Increased BP
3. Deranged renal function

Question 8

Intervention for diabetic nephropathy (3)

Answer 8

1. diabetic control
2. BP control
3. inhibition of activity of RAS system

Question 9

2 effects of an ACE inhibitor on diabetic nephropathy + effect of ACEi on creatinine within a few days

Answer 9

reduces incidence + rate of progression

increase creatinine (worsens a little bit)

Question 10

would you prescribe ACEinhibitors to bilateral renal artery stenosis?

Answer 10

No it is contraindicated because it can lead to zero GFR renal failure

but you would in unilateral

Question 11

Treatment for 1) background diabetic retinopathy

2) pre-proliferative dr
3) proliferative dr

Answer 11

1= improve blood glucose control
2= pan-photocoagulopathy
3= pan-photocoagulopathy