Doxycycline Hyclate (Tetrecycline Antibiotic)

Question 1

What is the brand name of doxycycline hyclate?

Answer 1

Vibramycin, Doryx

Question 2

What strength tablets are available for doxycycline hyclate?

Answer 2

20 mg and 100 mg

Question 3

What strength capsules are available for doxycycline hyclate?

Answer 3

50 mg and 100 mg

Question 4

What strength delayed release tablets are available for doxycycline hyclate?

Answer 4

75 mg, 100 mg, 150 mg

Question 5

What strength syrup is available for doxycycline hyclate?

Answer 5

50 mg per 5 mL (as calcium salt)

Question 6

What strength powder for oral suspension of doxycycline hyclate is available?

Answer 6

25 mg as monohydrate per 5 mL after reconstitution, raspberry flavor

Question 7

What strength powder for injection is available for doxycycline hyclate?

Answer 7

100 mg and 200 mg per vile

Question 8

What dose of doxycycline hyclate is used to treat primary and secondary syphilis?

Answer 8

300 mg per day in divided doses for at least 10 days

Question 9

What strength of doxycycline hyclate is used to treat uncomplicated gonorrhea?

Answer 9

100 mg twice a day for seven days or 300 mg stat followed in one hour by a second 300 mg dose

Question 10

What dose of doxycycline hyclate is used to treat uncomplicated urethral, endocervical, or rectal infections due to chlamydia trachomatis?

Answer 10

100 mg twice a day for at least seven days

Question 11

What dose of doxycycline hyclate is used as a prophylaxis of malaria due to plasmodium falciparum and short term travelers to areas with strains resistant to other therapy?

Answer 11

100 mg daily beginning to days prior to departure and continuing for four weeks after return

Question 12

What dose of doxycycline hyclate is used in children over eight years old?

Answer 12

4.4 mg/kg initially and two divided doses followed by 2.2 to 4.4 mg/kg per day

Question 13

What dose of doxycycline hyclate is used to treat infections due to susceptible strains of gram-negative/gram-positive bacilli & cocci, spirochetes, Mycoplasmic pneumonia, actinomycetes and rickettsia?

Answer 13

100 mg every 12 hours on the first day followed by 100 to 200 mg per day and one or two divided doses

Question 14

What should the providers monitor when the patient is taking doxycycline hyclate?

Answer 14

Complete blood count

Question 15

What is the mechanism of action for doxycycline hyclate?

Answer 15

Doxycycline is a tetracycline anabiotic which prevents bacterial proteins synthesis by competitively binding to the 30 S ribosomal subunits

Question 16

What are the drug interactions for Vibramycin?

Answer 16

• May impair the action of bactericidal antibiotics.
• May impair the systemic absorption of oral contraceptives.
• May increase the bioavailability of digoxin.
• Absorption impaired by aluminum, bismuth, calcium, magnesium, zinc and iron salts, and urinary alkalinizes.
• use with methoxyflurane may produce nephrotoxicity.

Question 17

What are the contraindications for doxycycline hyclate?

Answer 17

• Contraindicated in patients hypersensitive to any tetracycline.
• Use with caution in children under eight years of age (during tooth development) and in patients with impaired renal function.
• Cases of clostridium difficile associated diarrhea have occurred during treatment with tetracyclines.
• Persistent or severe diarrhea should be reported to a physician
• Use in lactation only ff benefits clearly outweigh risks.
• Pregnancy category D

Question 18

What are the adverse effects of doxycycline hyclate?

Answer 18

Dizziness, vertigo, nausea, vomiting, diarrhea, increased sensitivity to sunlight, discoloration of forming teeth, sore or darkened tongue, cramps and burning stomach.

Question 19

What should the RPh tell the patient when counseling them for doxycycline hyclate?

Answer 19

• Preferably taken on an empty stomach one hour before or two hours after meals with a full glass of water (240mL)
• May be taken with food or milk if GI upset occurs.
• Take in even intervals, preferably around the clock.
• Complete full course of therapy unless otherwise directed.
• Shake suspension well before using.
• Avoid prolonged exposure to sunlight.
• If a dose is missed, take it as soon as possible.