Doxycycline Hyclate (Tetrecycline Antibiotic) Flashcards
What is the brand name of doxycycline hyclate?
Vibramycin, Doryx
What strength tablets are available for doxycycline hyclate?
20 mg and 100 mg
What strength capsules are available for doxycycline hyclate?
50 mg and 100 mg
What strength delayed release tablets are available for doxycycline hyclate?
75 mg, 100 mg, 150 mg
What strength syrup is available for doxycycline hyclate?
50 mg per 5 mL (as calcium salt)
What strength powder for oral suspension of doxycycline hyclate is available?
25 mg as monohydrate per 5 mL after reconstitution, raspberry flavor
What strength powder for injection is available for doxycycline hyclate?
100 mg and 200 mg per vile
What dose of doxycycline hyclate is used to treat primary and secondary syphilis?
300 mg per day in divided doses for at least 10 days
What strength of doxycycline hyclate is used to treat uncomplicated gonorrhea?
100 mg twice a day for seven days or 300 mg stat followed in one hour by a second 300 mg dose
What dose of doxycycline hyclate is used to treat uncomplicated urethral, endocervical, or rectal infections due to chlamydia trachomatis?
100 mg twice a day for at least seven days
What dose of doxycycline hyclate is used as a prophylaxis of malaria due to plasmodium falciparum and short term travelers to areas with strains resistant to other therapy?
100 mg daily beginning to days prior to departure and continuing for four weeks after return
What dose of doxycycline hyclate is used in children over eight years old?
4.4 mg/kg initially and two divided doses followed by 2.2 to 4.4 mg/kg per day
What dose of doxycycline hyclate is used to treat infections due to susceptible strains of gram-negative/gram-positive bacilli & cocci, spirochetes, Mycoplasmic pneumonia, actinomycetes and rickettsia?
100 mg every 12 hours on the first day followed by 100 to 200 mg per day and one or two divided doses
What should the providers monitor when the patient is taking doxycycline hyclate?
Complete blood count
What is the mechanism of action for doxycycline hyclate?
Doxycycline is a tetracycline anabiotic which prevents bacterial proteins synthesis by competitively binding to the 30 S ribosomal subunits
What are the drug interactions for Vibramycin?
- May impair the action of bactericidal antibiotics.
- May impair the systemic absorption of oral contraceptives.
- May increase the bioavailability of digoxin.
- Absorption impaired by aluminum, bismuth, calcium, magnesium, zinc and iron salts, and urinary alkalinizes.
- use with methoxyflurane may produce nephrotoxicity.
What are the contraindications for doxycycline hyclate?
- Contraindicated in patients hypersensitive to any tetracycline.
- Use with caution in children under eight years of age (during tooth development) and in patients with impaired renal function.
- Cases of clostridium difficile associated diarrhea have occurred during treatment with tetracyclines.
- Persistent or severe diarrhea should be reported to a physician
- Use in lactation only ff benefits clearly outweigh risks.
- Pregnancy category D
What are the adverse effects of doxycycline hyclate?
Dizziness, vertigo, nausea, vomiting, diarrhea, increased sensitivity to sunlight, discoloration of forming teeth, sore or darkened tongue, cramps and burning stomach.
What should the RPh tell the patient when counseling them for doxycycline hyclate?
- Preferably taken on an empty stomach one hour before or two hours after meals with a full glass of water (240mL)
- May be taken with food or milk if GI upset occurs.
- Take in even intervals, preferably around the clock.
- Complete full course of therapy unless otherwise directed.
- Shake suspension well before using.
- Avoid prolonged exposure to sunlight.
- If a dose is missed, take it as soon as possible.
