Amoxicillin Trihydrate (Penicillin Antibiotic)

Question 1

What is the brand name of amoxicillin trihydrate?

Answer 1

Amoxil, Moxatag, Trimox

Question 2

What strength chewable tablets are available for amoxicillin trihydrate?

Answer 2

125 mg and 250 mg

Question 3

What what strength tablets of amoxicillin trihydrate are available?

Answer 3

500 mg and 875 mg

Question 4

What strength extended release tablets are available for amoxicillin trihydrate?

Answer 4

775 mg (Moxatag)

Question 5

What strength capsules are available of amoxicillin trihydrate?

Answer 5

250 mg and 500 mg

Question 6

What strength powder for oral suspension is available for amoxicillin trihydrate?

Answer 6

125mg/5mL
200mg/5mL
250mg/5mL
400mg/5mL
 (all after reconstitution)

Question 7

What is the FDA approved indication for amoxicillin trihydrate?

Answer 7

Used to treat infections due to susceptible strains of the following gram-negative organisms: H. influenzae, E. coli, P. mirabilis, and N. gonorrhoeae.

Also indicated in certain infections caused by susceptible strains of the following gram-positive organisms: streptococci (including S. faecalis), nonpenicillinase-producing staphylococci, & D. pneumoniae

Question 8

What dose of amoxicillin is used when treating infections in adults and children?

Answer 8

Adults: 250 mg to 500 mg every eight hours or 500 mg to 175 mg every 12 hours

Children: 20 to 45 mg/kg/day and equally divided doses. 125 mg and 250 mg formulations are given every eight hours while 200 mg at 400 mg formulations are given every 12 hours.

Question 9

What dose of amoxicillin trihydrate is used to treat gonorrhea and acute uncomplicated urethral and anogenital infections due to N. gonorrhoeae?

Answer 9

Adults: 3 grams as a single dose

Prepubertal Children over 2 years: 50mg/kg amoxicillin combined with 25mg/kg probenecid as a single dose.

Question 10

What is the mechanism of action of amoxicillin trihydrate?

Answer 10

Amoxicillin inhibits bacterial cell wall synthesis theory isolation of the transpeptidase enzyme.

Question 11

What are the drug interactions of amoxicillin trihydrate?

Answer 11

• Changes in G.I. flora may disrupt the absorption of oral contraceptives.
• Theoretically should not be used with bacteriostatic antibiotics because bactericidal antibiotics depend on the rapid growth of bacteria to exert their pharmacological affect.
• Renal excretion will be decreased with probenecid

Question 12

What are the contra indications of amoxicillin trihydrate?

Answer 12

• Contraindicated in patients hypersensitive to penicillin and/or cephalosporins
• The estimated incidence of cross sensitivity is 5% to 16%.
• Use with caution in patients with renal function impairment.
• Cases of pseudomembranous colitis have occurred during treatment with cephalosporins.
• Persistent or severe diarrhea should be reported to a physician.
• Pregnancy Category B

Question 13

What are the adverse effects of amoxicillin trihydrate?

Answer 13

Nausea, vomiting, diarrhea, hives, itching, and rash

Question 14

What should the RPh tell the patient in counseling them for amoxicillin trihydrate?

Answer 14

• Preferably taken on an empty stomach one hour before or two hours after meals with a full glass of water (240 mL).
• Chewable tablets must be chewed before swallowing or they can be crushed and mixed with food.
• Take at even intervals, preferably around the clock.
• Complete full course of therapy unless otherwise directed.
• Keep suspension refrigerated, discard after 14 days.
• If a dose is missed, take it as soon as possible.