Dosing

Question 1

Dose of diclofenac

Answer 1

• 50 mg q8-12 hours
• Max 150 mg daily

Question 2

Dose of ibuprofen

Answer 2

• 400 mg q4-6 hours
• Max 3200 mg (acute) or 2400 mg (chronic) per day

OTC:
200 mg TDS

Question 3

Dose of naproxen sodium

Answer 3

• 275 -550 mg q12 hours
• Max 1375 mg (acute) or 1100 mg (chronic)

OTC:
- 220 mg q8-12 hours

Question 4

Dose of celecoxib

Answer 4

• 200 mg daily or 100 mg q12 hours
• Max 400 mg per day

Question 5

Dose of etoricoxib

Answer 5

• 30-60 mg once daily
• Max 120 mg (acute up to 8 days) or 60 mg (chronic) per day

Question 6

Dose of methotrexate

Answer 6

• Initial: 7.5 mg once weekly
• Increase 2.5-5 mg / week q4-12 weeks
• Target: 15 mg / week within 4-6 weeks of initiation
• Max 25 mg / week

Question 7

Dose of sulfasalazine

Answer 7

• Initial 500 mg OD or BD
• Increase by 500 mg / week
• Target: 1 g BD
• Max 3 g/day

Question 8

Dose of hydroxychloroquine

Answer 8

• 200-400 mg in 1-2 divided doses
• Max 5 mg/kg/day

Question 9

Dose of leflunomide

Answer 9

• 100 mg/day x 3 days
• Followed by 20 mg daily

Question 10

Dose of glucocorticoids for RA bridge

Answer 10

Not more than 7.5 mg of prednisolone per day for 3 months

Question 11

Dose of colchicine

Answer 11

Either:
- One-off treatment with 1 mg loading dose
- Followed by a single dose of 0.5 mg one hour later

or

• 0.5 mg BD or TDS until flare resolution

Max 1.5 mg daily

Question 12

Dose of allopurinol

Answer 12

• Initiate not more than 100 mg per day (or 50 mg in CKD)
• Titrate with 50-100 mg increments q2-8 weeks
• Usual maintenance dose > 300 mg per day
• Max 800-900 mg per day

Question 13

Dose of febuxostat

Answer 13

• Initiate not more than 40 mg per day
• Increase to 80 mg per day if target not met after 2-4 weeks

Question 14

Dose of probenecid

Answer 14

• Initiate 250 mg BD x 1 week, f/b 500 mg BD
• Titrate with 500 mg increments q4 weeks if not controlled
• Usual maintenance dose at most 2 g per day

Question 15

Dose of romosozumab

Answer 15

SC once monthly, up to 12 months

Question 16

Dose of zolendronic acid

Answer 16

IV 5 mg every year as a 30 min infusion. Ensure adequate hydration prior to infusion.

Question 17

Dose of risedronate

Answer 17

PO 35 mg every week

Question 18

Dose of ibandronate

Answer 18

PO 150 mg monthly

Question 19

Dose of alendronate

Answer 19

PO 70 mg every week

Question 20

Dose of denosumab

Answer 20

SC once every 6 months

Question 21

Dose of calcium supplementation

Answer 21

1000 mg elemental Ca per day (>50 y.o.)
800 mg elemental Ca per day (50 y.o. and below)
Supplement if daily intake 700 mg elemental Ca/day

Question 22

Dose of vit D supplementation

Answer 22

800 IU per day

Question 23

Dose of meloxicam

Answer 23

7.5-15 mg OD
Max 15 mg

Question 24

Dose of voltaren gel

Answer 24

1% diclofenac
3-4 times/day
Max 2-3 weeks

Question 25

Dose of kefentech plaster

Answer 25

30 mg ketoprofen
BD
Max 10 days

Question 26

Dose of fastum gel

Answer 26

2.5% ketoprofen
2-3 times/day
Max 10 days

Question 27

Dose of paracetamol

Answer 27

1000 mg q6 hours, up to TDS
Max 3000 mg
4000 mg if clinically supervised

Question 28

Dose of anarex

Answer 28

450 mg paracetamol + 35 mg orphenadrine
2 tablets q6 hours, up to TDS
Max 6 tablets

Question 29

Dose of tramadol

Answer 29

25-50 mg TDS
Max 400 mg

Question 30

Dose of glucocorticoid for acute gout

Answer 30

30-40 mg OD, up to 0.5 mg/kg/day
Until gout resolution, taper off over 7 days