Dopamine Research For A03

Question 1

Strength dopamine hyp - leucht et al

Answer 1

Meta analysis of 212 studies and concluded all psychotic drugs tests in these studies were significantly more effective than placebo in treatment of pos + neg symptoms, achieved by reducing effects of dopamine.

Supports dopamine hyp as success of drug treatments that attempt to change levels of dopamine activity in brain

Question 2

Research to refute dopamine hyp (other)

Answer 2

Evidence for centra role of glutamate
Scanning studies have consistently found raised levels of neurotransmittter glutamate in several regions of brain of people with schiz (mccutcheon)
Several candidate genes for schiz r belied to be involved in glutamate production
Means equally strong case can be made for role of other nts