Dopamine Flashcards

1
Q

What happens every time you impulse search or click on link on the internet?

A

It messes with your dopamine, with your mesolimbic system in a very similar manner to PMO or gaming. ANd this will remarkedly cut into your motivation, energy, and focus capacity.

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2
Q

1st strategy to do everytime you feel like surfing the internet or clicking on a link to take a break?

A

1) remind yourself of card 1. 2) meditate or 1min exercise (e.g. calf raises)

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3
Q

Alex Becker on how your brain works?

A

It’s always looking for the shortest path to achieve certain goals

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4
Q

Alex Becker on how dopamine works

A

It’s used to reward/motivate yourself to achieve goals

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5
Q

Alex Becker on why your motivation is low

A

Your motivation’s low because video games, phones, consuming info from internet, porn have all hijacked your brain, making your brain think those are real goals and behaviors. Since it’s a shorter path to achieve those goals than real behavior, your brain will release dopamine to motivate you to do those virtual things and not real things

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6
Q

What are two interesting things about the rats pressing the dopamine levers?

A

it replaced their motivation for beneficial, evolutionarily vital tasks like eating. They literally stopped eating. 2) they literally would walk across electric shocks to hit the dopamine levers

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7
Q

Salamone’s dopamine hypothesis

A

the primary function of dopamine is to regulate energy expenditure - [https://www.yourbrainonporn.com/relevant-research-and-articles-about-the-studies/dopamine-receptors/putting-desire-on-a-budget-dopamine-and-energy-expenditure-reconciling-reward-and-resources-2012/]

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8
Q

Salamone 1991 and 1994 studies

A

demonstrated that under free-feeding conditions, preference is not altered by changes in dopamine function; that is, dopamine does not increase incentive or alter food preference when no (or low) work requirement is present. In his studies, however, when obtaining a preferred food is associated with a response cost, dopamine increases the effort an animal will exert

https://www.yourbrainonporn.com/relevant-research-and-articles-about-the-studies/dopamine-receptors/putting-desire-on-a-budget-dopamine-and-energy-expenditure-reconciling-reward-and-resources-2012/

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9
Q

Robinson and Berridge 1993 study

A

famously described a dissociation between “wanting” and “liking” in addiction where addicts develop “wanting” for drugs without “liking”; that is, the incentive driving compulsive drug seeking is independent of its hedonic consequences

https://www.yourbrainonporn.com/relevant-research-and-articles-about-the-studies/dopamine-receptors/putting-desire-on-a-budget-dopamine-and-energy-expenditure-reconciling-reward-and-resources-2012/

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10
Q

According to Salamone, dopamine does not modulate desire, it puts it on an _________

A

energy budget

https://www.yourbrainonporn.com/relevant-research-and-articles-about-the-studies/dopamine-receptors/putting-desire-on-a-budget-dopamine-and-energy-expenditure-reconciling-reward-and-resources-2012/

[q: so then what does modulate desire???]

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11
Q

quinpirole

A

a D2 agonist

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12
Q

what are the three ways generalized activity is measured in rodents?

A

measured using either the open-field, running wheels or homecage activity monitors

https://www.yourbrainonporn.com/relevant-research-and-articles-about-the-studies/dopamine-receptors/putting-desire-on-a-budget-dopamine-and-energy-expenditure-reconciling-reward-and-resources-2012/

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13
Q

deltaFosB is like a

A

a sustained molecular switch for addiction [https://www.pnas.org/content/98/20/11042.full]

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14
Q

how long does it take for deltaFosB to decline

A

6-8 weeks. https://www.yourbrainonporn.com/ybop-articles-on-porn-addiction-porn-induced-problems/the-porn-debate/porn-pseudoscience-and-deltafosb-2013/

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15
Q

We are all hardwired to ______

A

consume resources in excess of daily requirements . I can’t think of a species that doesn’t” - Mark Edwards, animal nutritionist

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16
Q

Mark Edwards

A

Animal nutritionist

17
Q

Adolescents vs adults on deltafosb

A

Adolescent animals show much greater induction of ΔFosB compared with older animals, consistent with their greater vulnerability for addiction.

https://www.yourbrainonporn.com/ybop-articles-on-porn-addiction-porn-induced-problems/the-porn-debate/porn-pseudoscience-and-deltafosb-2013/

18
Q

high level summary of the deltaFosB overconsumption feedback loop

A

continued over-consumption leads to accumulation of ΔFosB → activation of genes → changes in synapses → addiction-related brain changes → cravings, compulsions → continued overconsumption

19
Q

How long does /u/dasaad3 say it takes to get your dopamine receptors reset?

A

90 days

20
Q

agonist

A

a chemical that binds to a receptor and activates the receptor to produce a biological response

21
Q

are you no longer addicted after deltaFosB declines?

A

not necessarily. your sensitized neural pathways can still exist.

22
Q

Alex Becker on timeline of a dopamine detox

A

first 2 days are hard. day 3 you noticeably have more motivation for the things that matter. day 5 is when you really start to get a lot of motivation.