Domestication 1

Question 1

Domesticated species

Answer 1

40,000 species
200 domesticated
80% of domesticated are corn,maize,barley,sorghum,rice
Have to have domestication traits-zebra too vicious

Question 2

Human domestication

Answer 2

Lactose persistence

Lactose cannot be digested in the gut and so provides energy to gut bacteria-bloating, flatulance and diarrhoea

Question 3

Lactose persistence

Answer 3

Advantageous so spread over Europe
Point mutation in MCM6 regulatory region of lactose gene
C13910T mutation

Question 4

Identify domestication genes

Answer 4

Genetics, candidate gene approach, genomes

Question 5

Genetics

Answer 5

Cross domesticated and non domesticated species and follow progeny.
Selecte genes responsible for domesticated phenotype and map on QTL map
Clone genes from map

Question 6

Genomes

Answer 6

Sequence many genomes and associate features of domestication with areas of DNA that are associated with genes

Question 7

Candidate gene approach

Answer 7

Work out how process works in model organism
Identify genes that are responsible for the trait in model organism
Investigate the gene in the domesticated species

Question 8

Stages of domestication

Answer 8

1- look for mutation that has advantageous phenotype
2- in situ increase freq of desired allele, cultivate further from wt and increase diversity of phenotype so
3- cultivate particular lines for particular purposes
4- deliberate breeding for certain traits, eg. Sweetness, resistance, yield