Doc Layug - NSAID drugs

Question 1

A protein complex that controls TRANSCRIPTION of DNA and also plays a key role in regulating the immune response to infection. Imbalance to this causes inflammation, Ca, autoimmune response.

Answer 1

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)

Question 2

A prostaglandin member of the family of lipid molecules known as eicosanoids. It inhibits platelet activation and is also an effective VASODILATOR. (cardioprotective siya)

Answer 2

Prostacyclin (also called prostaglandin I2 or PGI2)
EPOPROSTENOL siya pag drug.

iba pang eicosanoid:
thromboxanes (Vasoconstrictor)
leukotriene

Question 3

NSAID prototype

Answer 3

ASPIRIN, IBUPROFEN

Question 4

5 cardinal signs of inflammation

Answer 4

Rubor (Redness),
Calor (Heat),
Tumor (swelling),
Dolor (pain), and
Functio Laesa (loss of function).

Question 5

2 answers
Inducer of COX 2 pathway except
a. Cytokines IL -1, 
b. Growth factor
c. TNF
d. Cytokines IL - 4
e. Glucocorticoids

Answer 5

D and E. negative effect/inhibitor sila sa COX 2 pathway

Question 6

MOA of ASPIRIN

Answer 6

IRREversible Acetylation of COX 1

Question 7

Pharmacokinetics of NSAID
Most are (well, poorly) absorbed
Food (change, does not change) their bioavailability
Renally (excreted, absorbed)
(Highyly, Not) protien bound

Answer 7

Most are WELL absorbed
Food DOES NOT CHANGE their bioavailability
Renally EXCRETED
HIGHLY protien bound

addtional
Most are found in synovial fluid after repeated dosing. Kaya siya effective sa arthritis. :)

Question 8

COX 1 VS COX 2

1. Selectivity is variable in COX _____
2. Platelet function is more with COX _____
3. GI disturbance is LESS with COX ______
4. Risk for edema and hypertension is HIGHER in COX _____

Answer 8

1. Selectivity is variable in COX 1
2. Platelet function is more with COX 1
3. GI disturbance is LESS with COX 2
4. Risk for edema and hypertension is HIGHER in COX 2