Doc Abella - Introduction sa CNS drugs

Question 1

This give the G-protein type (Gq, Gi, or Gs) for all the receptors.

Answer 1

alpha1=Q
alpha2=I
beta1=S
beta2=S
M1=Q
M2=I
M3=Q
D1=S
D2=I
H1=Q
H2=S
V1=Q
V2=S

alphabetically arranged sila.

“QISS and QIQ until you’re SIQ of Super Qinky Sex”
Kiss and kick until you’re sick of super kinky sex

Question 2

What receptors activates the PHOSPHOLIPASE C pathway?

a. H1, A1, V1, M1 and M3
b. M2, A2, D2
c. B1, B2, D1, H2, V2
d. none

Answer 2

A. HAV 1 M&M (have 1 m&m”)
- Phospholipase C pathway to DAG to PROTEIN KINASE C or IP3 to inc Calcium

B. MAD 2’s - Adenylyl cyclase pathway (ATP to CAMP) to PROTEIN KINASE A

c. pareho ng B.

Question 3

Depletes monoamine synapses of transmitters by interfering with intracellular storage

Answer 3

Reserpine

Question 4

Induces the release of catecholamines from adrenergic synapses

Answer 4

Amphetamine

Question 5

causes the release of the peptide substance P from sensory neurons and tetanus toxin blocks the release of transmitters

Answer 5

Capsaicin

Question 6

blocks the uptake of catecholamines at adrenergic synapses and thus potentiates the action of these amines

Answer 6

Cocaine

Question 7

Block the degradation of acetylcholine and thereby prolong its action

Answer 7

• Anticholinesterases

Question 8

Receptor blocker at cholinergic synapses, but acts at nicotinic receptors → blocks transmission at neuromuscular junctions → paralyzing its recipients and killing them by blocking their respiration

Answer 8

• Curare

Question 9

A neurotoxin released by a bacterium, blocks the release of acetylcholine at neuromuscular junctions and is thus a deadly poison

Answer 9

• Botox

short for Botulinium toxin