Doc Cocoy Calderon - Antiseizure Drugs Flashcards
Drug that causes GINGIVAL HYPERPLASIA, diplopia, ataxia, hirsutism, and FETAL HYDATOIN SYNDROME
a. Phenytoin
b. Valproic Acid
c. Ethosuximide
d. Clonapezam
A
Which of the following is an INHIBITOR of CYP450 enzyme? a Phenytoin b. Valproic Acid c. Carbamazepine d. Phenobarbital
B. Lahat na ng natira ay inducer
Which of the following is NOT a characteristic of Phenytoin?
a. Inducer of CYP450 enzyme
b. Extensively protein bound
c. Follows zero-order kinetics at high doses
d. Clinical use is for Grandmal Seizure
e. None of the above
E
DOC for JUVENILE MYOCLONIC EPILEPSY
a. Ethosuximide
b. Phenytoin
c. Valproic acid
d. Lamotrigine
C
Drug that causes GI Distress, Hepatotoxicity, Neural tube defects
a. Ethosuximide
b. Phenytoin
c. Valproic acid
d. Lamotrigine
C.
Drug which MOA causes DECREASE THRESHOLD Ca current T-types in Thalamus
a. Phenytoin
b. Valproic Acid
c. Ethosuximide
d. Clonapezam
C.
Preferred ANTISEIZURE drug for Pregnant and children with Febrile seizure?
Phenobarbital
Drug that acts BLOCKS volted-gated NA+ channels by SLOWING the RATE OF RECOVERY of voltage-activated Na+ channels
Carbamazepine
Drug that Binds GABA receptor subunits to INCREASE FREQUENCY of CHLORIDE CHANNEL OPENING.
DIAZEPAM.
Phenobarbital causes INCREASE DURATION of CHLORIDE CHANNEL OPENING.
Drug that causes STEVEN JOHNSON SYNDROME
LAMOTRIGRINE
Drug that causes ANTEROGRADE AMNESIA, UNWANTED DAYTIME SEDATION, Decreased psychomotor skills, respiratory depression, dependence liability
Clonazepam
Drug that has MULTIPLE action on synaptic function and causes Psychomotor slowing, Memory impairment, Glaucoma, Urolithiasis, and Acute Myopia
TOPIRAMATE
The Drugs of choice for Grand-Mal Seizure includes
a. Valproic Acid, Phenytoin, Carbamazepine
b. Carbamazepine, Lamotrigine, Phenytoin
c. Ethosuximide, Valproic acid
d. Valproic acid
e. Larazepam, Diazepam, Phenytoin, Phenobarbital
a. Valproic Acid, Phenytoin, Carbamazepine ( Grand - mal)
b. Carbamazepine, Lamotrigine, Phenytoin (Partial)
c. Ethosuximide, Valproic acid (Absence Seizure)
d. Valproic acid(Myoclonic and Atypical Absence Syndrome)
e. Lorazepam, Diazepam, Phenytoin, Phenobarbital (Status Epilipticus)
Drug that increases GABA release and decreases release of glutamate. It’s clinical use us for NEUROPATHIC PAIN, and MIGRAINE
GABApentin
Drug that binds synaptic vesicular protein SV2A and has side effects of dizziness, sedation, weakness, hallucinations and psychosis
Levetiracetam
Drug that is used as a first line drug for Bipolar Affective Disorders, specifically MANIA
Valproic acid
