DOC Cards Flashcards
What is the DOC for early or late syphillis
PCN G benzathine
What is the DOC of rPCN Sensitive Gangrene (C. Perfringens)
1* gen PCN
DOC of PCN Endocarditis
1* PCN
WHAT PCN should be used on MSSA Endocarditis
D.O.N.
Dicloxacillin
Fafcillin
Oxacillin
What is the 1st line DOC in OTitis Media
Amoxicillin
What is the DOC in early animal bites
Augmentin
DOGmentin
What is the DOC in late animal bites
Ampicillin/ Sulbactam
What PCN can be used in UTI pregnant pts
Amoxicillin or Ampicillin
What ABX is used for endocarditis prophylaxis
Amoxicillin PO
What is the ABX used for H. Pylori (Duodenal)
Amoxicillin PO
Ampicillin IV + Aminoglycosides can be used for..
Meningitis
Ampicillin IV + Macrolides or Doxycycline can be used for
CAP
What is the ABX combination used in OM resistant to amoxicillin
Augmentin (Amoxicillin/ Clauvanic Acid)
In human bites, if the pt is allergic to PCN, use…
Clindamycin + ciprofloxacin or TMP/SMX
DOC in Gynecological infx caused by B- Lactamase producing E. Coli
Ampicillin/ Sulbactam (Unasyn) IV
What is the PCN combination used for HAP
Ampicillin/ Sulbactam
Piperacillin+ Tazobactam is used for
Pseudomonas Coverage (Often combined with Aminoglycosides)
Which two PCN cover Abdominal Anaerobes
Piperacillin/ tazobactam
Ampicillin/. Sulbactam
What is the DOC for pre/post surgery not involving the Abdomen
Cefazolin IV (Ancef)
What are the Cephalosporins for surgery prophylaxis involving the abdomen
Cefoxitin and Cefotetan
2* gen cephalosporins
What is the DOC to tx N. Gonorrhea and Complicated pyleonephritis
Ceftriaxone
3* Cephalosporin
CAn neonates metabolize Ceftriaxone
NO
What is the Cephalosporin DOC for CNS penetration
Ceftriaxone
All 3* tends have good CNS penetration, however Ceftriaxone is DOC
What is the broadest spectrum Cephalosporin
Cefepime
What is the cephalosporin of r empiric therapy in critically ill high risk PTs (HAP, VAP, Comp UTI) a
Cefepime
4* gen Cephalosporin
What is the clinical use of 5* gen cephalosporin Ceftaroline
MRSA (SSTI)
What gen Cephalosporins are used for OM
1* and 2*
What 2 Cephalosporin cover pseudomonas
Cefepime and Ceftazadime
Why is Imipenem and Cilastatin always given together
Imipenem is metabolized in the kidney to a nephrotoxic product
Cilastatin blocks the renal dehydropeptidase that catalyzes this reactions and prevent this metabolism from occurring
Which Carbapenems has the highest risk of SZR
Imipenem @ >4g/d
What is the name of the monobactam that can be used in PCN/ cephalosporin allergic pts
Aztreonam
Aztreonam has cross reactivity with what 3*gen cephalosporin
Ceftazadime
What 2 Carbapenems cover psuedomonas
Azteronam and Meropenem
Does Aztreonam cover MSSA
No
Which Carbapenems cover Anerobic abdominals
Ertapenem and Meropenem
What does Vancomycin cover
MRSA and MSSA
What is oral vancomycin used for
C. Diff
What is the coverage of Daptomycin
VRE, MRSA, MSSA
What is the major ADE of Daptomycin
Rhabdomyolysis
What can Daptomycin not be used for specifically
Pulmonary infx, it’s degraded by surfactant
What is the coverage of Colistimethate
Pseudomonas
What is the major ADE of Colistimethate
Nephro and Nuero Toxic
What is the DOC in pneumonia accosicated with cystic fibrosis
Colistimethate inhaled
Does Doxycycline cover pseudomonas
No
Of the tetracyclines (DMT), which have to be taken on an empty stomach, and which need renal adjustment
Tetracycline- Empty Stomach and avoid in renal dysfunction
What are the major ADE of tetracyclines (DMT)
N/V
TISSUE HYPERPIGMENTATION
Photosensitivity
Not Advised in Pregnancy/ Breasfeading/ or children under 8 yo
What is the 1* line agent DOC in tick borne diseases
Doxycycline
Which tetracycline (DMT) can be used for malaria
Doxycycline
Which tetracycline (DMT) can be used for chlamydia
Doxycycline
Aminoglycosides (GNT) have a synergistic effect with what other class of drugs
Cell wall inhibitors like β-Lactams, vancomycin, daptomycin
What is the coverage of Aminoglycosides (GNT)
Psuedomonas
Do Aminoglycosides (GNT) require renal adjustment
YES
Are Aminoglycosides (GNT) safe for pregnancy
No, Preg Cat D
What are the major ADE of aminoglycosides (GNT)
Nephro (reversible) and Oto toxicity (irreversible)
What is the coverage of Azithromycin
Atypicals
Mycoplasma, Chlamydia, Legionella
What are the Major ADE of Macrolides (Azithromycin and Clarithromycin)
QT elongation
Hepatic and Gastrointestianl RXNs
What is the preg cat for MAcrolides (Azithromycin and Clarithromycin)
Azithromycin- B
Clarithromycin-C
Of the Macrolides (Azithromycin and Clarithromycin)
Which has the lower DDI
Azithromycin (does not significantly inhibit CYP3A4
Can macrolides (Azithromycin and Clarithromycin) be used on Endocarditis or Meningitis
NO! They are not bactericidal
What is the use of Azithromycin
Chlamydia
Upper and lower RTI
What is the use of Clarithromycin
Upper and lower RTI
H. Pylori induced GI ulcer
Does clindamycin cover psuedomonas
NO
What is the coverage of Clindamycin
MRSA, MSSA, abdominal anaerobes and Atypicals
What is the major ADE of clindamycin
C. Diff and Steven-Johnson Syndrome
Is clindamycin safe for pregnancy
Yes, Cat B
What is the use of Oral/ IV clindamycin
SSTI, MRSA, Nec Fasc, Polymicrobial INfx in DM
What is the second line agent in Penicillin/ Cephalosporin allergic pts
Clindamycin
What is Topical Clindamycin used for
Acne and BV
What is the coverage of linezolid
VRE, MRSA, MSSA
What is the preg cat for linezolid and does it require renal adjust
C , and No
Can linezolid be used for bacteremia
NO, its too widely distributed
What is linezolid used for
Nosocomial pneumonia
CAP complicated and uncomplicated
SSTI
What is the major ADE of linezolid
Anemia, Luekopenia, pancytopenia, thrombocytopenia
Weak MAO inhibitor (serotonin syndrome)
What two fluoroquinolones cover Pseudomonas
Ciprofloxacin and Levofloxacin
Which fluoroquinolones covers anaerobes
Moxifloxacin
What is the coverage of Moxifloxacin
MSSA, And Atypicals
What is the coverage of ciprofloxacin
Psuedomonas and Atypicals
What is the major ADE of Fluoroquinolones (CLeM)
Mainly in elderly/critically ill can cause hallucinations, delirium, seizures
Rashes
Photosensitivity
Risk to athletes (tendon rupture)
Variable QTC
What is the risk to athletes taking fluoroquinolones (CLeM)
Tendon Rupture, for up to 6 months post course
Besides tendon rupture for athletes what are the other ADE of fluoroquinolones
Tendon rupture for pts older than 60, taking corticosteroids, or in renal failure
Athralgias in pts less than 18 y/o
Variable QTC elongation
What is the pregnancy cat and absorption advisory for Fluoroquinolones (CLeM)
Cat C
Reduced by anti acids for absorption
-penetrated CNS and Bone
What is the DOC for anthrax
Ciprofloxacin
Can Moxifloxacin be used for UTI
No
What is the Fluoroquinolones DOC for p. Aeruginosa RTI
Levofloxacin
Which fluoroquinolones has the best anerobic coverage
Moxifloxacin
What ABX can not be used with a G6PD def.
Sulfonamides Nitrofurantoin Dapsone Primaquine Quinidine
What is the DOC for toxoplamsa Gondi
Sufladiazine
What is the coverage for Sulfamethoxazole and Trimethoprim
MRSA, MSSA
Can Sulfonamides be used in neonates
NO!
Pump and dump,
Causes congenital malformations
How are sulfanomides excreted
Renally, concentrates in the urine
Do Sulfonamides penetrate CNS
Yes
What is the folate synth inhibitor that is used to treat Pneumocystis pneumonia (PCP)
SMX/TMP
What are the Major ADE of Sulfonamides
Stevens Johnson Syndrome
Bien marrow Supresión
Hemolytic anemia with G6PD
Crystalurea
What is the DOC for Trichomonas vaginalis
Tinidazole or Metronidazole
What are the major ADE of Nitroimidazoles (metronidazole and Tinidazole)
Metallic taste
Warfarin DDI
Avoid in alcohol due to disulfiram RXNs
What is the DOC to cover amebiasis (E. Histolitica, Giardiasis, Trichomnas)
Metronidazole or Tindazole
Metronidazole when combined with a PPI can treat
H. Pylori
What is the DOC in nfections with documented or suspected abdominal anaerobic bacteria, with adjunctive coverage of aerobes by a second drug when necessary
Metronidazole or Tindazole
Nitroimidazoles
What is the more expensive version of vancomycin, used to treat C. Diff and is a protein synth inhibitor
Fidaxomicin
Fidaxomicin should not be used in what pts.
Pts with macrolide allergies (Azithromycin or clarithromycin)
Or in combination with vancomycin (destroys too much flora)
What is the DOC for impetigo
Mupirocin
What is the coverage of mupirocin
MRSA and group A strep
What is the DOC for MRSA in adult patients and healthcare workers during institutional outbreaks
Mupirocin
What is Nitrofurantoin used for
Uncomplicated cystitis and UTI
What is fosfomycin used for
Uncomplicated UTI
What is Methanamine used for
Uncomplicated UTI (prophylaxis and suppression only) not TX