Dobutamine (Dobutrex)

Question 1

Class

Answer 1

Adrenergic agent, inotropic

Question 2

Action

Answer 2

Acts primarily as an agonist at beta, adrenergic receptors with minor beta2 and alpha1 effects. Consequently, dobutamine increases myocardial contractility and stroke volume with minor chronotropic effects, resulting in increased cardiac output

Question 3

Indications

Answer 3

CHF, cardiogenic shock

Question 4

Adverse Effects

Answer 4

Tachycardia, PVCs, hypertension, hypotension, palpitations, arrhythmias

Question 5

Contraindications

Answer 5

Suspected or known poisoning/drug-induced shock, systolic blood pressure

Question 6

Dosage (Adult)

Answer 6

2 to 20 mcg/kg/min IV, IO. At doses >20 mcg/kg/min, increases of heart rate of >10% may induce or exacerbate myocardial ischemia

Question 7

Dosage (Peds)

Answer 7

Same as adult dosing

Question 8

Special Considerations

Answer 8

Half-life 2 mins; Pregnancy C