DNA Viruses- Name that Virus

Question 1

NA: DNA
Capsule: Envelope
Replicates: Cytoplasm- brings own RNA poly
Family Features: Large brick shaped; Virus encoded enzymes; Epidermal cells
Special Features: Lesions go hands/feet → trunk;
Indentation in lesions
Disease: Small pox, Inhalation, UR – dermal
After 2 rounds
Vaccine: Attenuated, can cause myocarditis

Answer 1

Poxviridae: Variola

Question 2

NA: DNA
Capsule: Envelope
Replicates: Cytoplasm- brings own RNA poly
Family Features: Large brick shaped; Virus encoded enzymes; Epidermal cells
Special Features: Lesions smooth firm, shiny Pearly white
Disease: Benign epidermal tumors; Direct contact / fomites

Answer 2

Poxviridae: Molluscum Contagiosum

Question 3

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Latency in sensory ganglia; Hijack microtubules system
Disease: Upper Body

Answer 3

Herpesviridae: HSV1 (Alpha HV)

Question 4

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Latency in sacral ganglia;
Hijack microtubules system
Disease: Genital Infections

Answer 4

Herpesviridae: HSV2 (Alpha HV)

Question 5

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Latent in ganglia; Lesions go trunk → hands/feet
Disease: Chicken pox; Respiratory; Birth defects – pregnant; Lymph nodes – spleen & Liver then skin and rash
Vaccine: attenuated

Answer 5

Herpesviridae: Varicella

Question 6

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Reactivation from ganglia
Disease: Shingles
Vaccine: attenuated

Answer 6

Herpesviridae: Herpes Zoster

Question 7

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Infected for life; CR2 of epithelial and B cells; B growth and prevent apoptosis
(controlled by CD8); Heterophile Ab – when fake IgM is being produced by B cells; Transmitted via saliva (kissing disease)
Disease: Infectious mononucleosis; Overactive immune resp.; Lymphocytosis – Atypical T (Downey cells); Lymphoma – lack of
Immune response; Burkitts, Hodgkins

Answer 7

Herpesviridae: Epstein-barr (EBV)

Gamma HV

Question 8

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: KSHV necessary for KS development in HIV; Is STD
Disease: KSHV; STD; Cancer in blood and lymph

Answer 8

Herpesviridae: HHV-8

Gamma HV

Question 9

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Latency in monocyte; Urine with virus – reactivation; Toddlers in daycare; Monospot negative mono
Disease: Heterophile negative Mononuelcosis; STD; Neuro damage fetus; Preg daycare - careful

Answer 9

Herpesviridae: Human Cytomegalo-Virus (CMV)

Beta HV

Question 10

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Infected for life; Latent in peripheral blood, Mononuclear cells, CD4 cells and epithelial of salivary; Chronic infection; Shed in saliva
Disease: Roseola Infantum (aka Exanthema subitum aka sixth disease); Fever (3-5 days) then
Maculopapular rash

Answer 10

Herpesviridae: HHV-6

Beta HV

Question 11

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus
Family Features: Inclusion bodies; Outer envelope from nuclear Membrane (budding)
Special Features: Most people infected

Answer 11

Herpesviridae: HHV-7

Beta HV

Question 12

NA: DNA
Capsule: Envelope, Icosahedral
Replicates: Nucleus; Hepatocytes Damaged by CD8+ T Cells
Family Features: Reverse transcriptase; knicked Circular DNA from nuclear Membrane (budding)
Special Features: HBcAg – core; HBsAg – neutralizing/decoy; HBeAg – breakdown of core
Incorporates in host chromosome; Latent-Coinfection with HDV
Disease: Serum hepatitis; STD or blood; Carries a risk for cancer And chronic liver diseases

Answer 12

Hepadnaviridae: HBV

Question 13

NA: DNA
Capsule: Naked, Icosahedral
Replicates: Nucleus
Family Features: Each penton with fiber and
Terminal knob
Disease: Acute Respiratory Disease (ARD), common cold, Croup, gastroenteritis, conjuncitivitis

Answer 13

Adenoviridae:

Question 14

NA: DNA
Capsule: Naked, Icosahedral
Replicates: Nucleus
Family Features: Smaller then adenoviridae; DNA integrates into host; Oncogenic, latent or chronic;
Transform nonpermissive cells
Special Features: Epidermosdyslplasia verruciformis- Skin warts sun - cancer
Disease: Benign skin wart; Condyloma acumata –
STD and ca
Vaccine: Gardasil – strains 6, 11, 16, 18 (Cancer and genital warts)
Cervavix 16, 18 (cancer)

Answer 14

Papovaviridae: HPV

Question 15

NA: DNA
Capsule: Naked, Icosahedral
Replicates: Nucleus
Family Features: Smaller then adenoviridae; DNA integrates into host; Oncogenic, latent or chronic;
Transform nonpermissive cells
Special Features: Can reactivate in 
immunocompromised people
Disease: Two Types: JC and BK; JC – latent infection in kidneys, B cells and Monocytes

Answer 15

Papovaviridae: Polyomaviridae

Question 16

NA: DNA
Capsule: Naked, Icosahedral
Replicates: Nucleus
Family Features: Tiny; Single stranded DNA
Special Features: Growth in erythroid precursor cells; UR and Bone marrow, drop in Hg; Rash due to ab
Disease: Erythema infectiosum; Slapped cheek in children

Answer 16

Parvovirade: Parvovirus B19