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Medical Virology > DNA viruses > Flashcards

DNA viruses Flashcards

1
Q

NAKED DNA VIRUSES

A

PARVOVIRIDAE
ADENOVIRIDAE
PAPOVAVIRIDAE

(PAR-AD-PAP)

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2
Q

ERYTHEMA INFECTIOSUM (FIFTH DISEASE)

  • sickle cell anemia, thalassemia, or spherocytosis
  • Second trimester: Hydrops Fetalis
  • ARTHRITIS
  • Respiratory Droplets
A

Parvovirus B-19

  • RBC destruction in fetus leads to hydrops fetalis and death, in adults leads to pure RBC aplasia and rheumatoid arthritis–like symptoms
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3
Q

The smallest DNA virus; the only DNA virus that is single-stranded.

A

PARVOVIRIDAE

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4
Q
  • Only virus with fiber
  • Cowdry type B intranuclear basophilic inclusion bodies
A

Adenovirus

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4
Q

The second smallest DNA virus

A

PAPOVAVIRIDAE

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5
Q
  • Koilocytes
  • Direct contact
  • Sexually transmitted
A

Human Papillomavirus (HPV)
- PAPOVAVIRIDAE

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6
Q

NOTE:
✅ Genital warts: Podophyllin
✅ Skin warts: Liquid nitrogen
✅ Plantar warts: Salicylic acid

PREVENTION:
✅ Vaccine for HPV 6, 11, 16, and 18 for females 9-26 years old

A

✨

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7
Q

causes hemorrhagic cystitis and nephropathy in patients with solid
organ (kidney) and bone marrow transplants

  • BKV blood test or a urine test for decoy cells
A

BK Polyoma Virus

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7
Q
  • Only causes disease in immunocompromised hosts
  • Causes progressive multifocal leukoencephalopathy in patients
    with AIDS

✅ Junky Cerebrum

A

JC Polyoma Virus (John Cunningham virus)

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8
Q

HPV type (?)

Genital warts (condyloma acuminata) Respiratory tract papillomas
Most common viral STD

A

HPV 6 and 11

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9
Q

Site of Latency of HSV-1 (HHV-1)

A

Trigeminal ganglia

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10
Q

Site of Latency of HSV-2 (HHV-2)

A

Lumbosacral ganglia

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11
Q

is the most common cause of sporadic, fatal encephalitis in the USA

A

HSV-1

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12
Q

principal target area of HPV

A

TEMPORAL LOBE:

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13
Q

NOTE:

HSV 1: saliva or direct
HSV 2: sexual or transvaginal

A

🐈

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14
Q

Cowdry Type A eosinophilic intranuclear inclusions

  • Vesicular rash (‘dewdrop on a rose petal appearance’) that begins on trunk; spreads to face and extremities
A

Varicella-Zoster Virus (VZV) / HHV-3

Period of communicability: 48 hours before vesicle formation and 4-5 days after until all vesicles are crusted

15
Q
  • owl’s-eye nuclear inclusion
  • Most common when the mother is infected in first trimester
  • Most common infectious cause of congenital abnormalities
  • Most common intrauterine viral infection

✅ Human body fluids
✅ Transplacental
⭐️ Organ transplantation

✅ Monospot-negative

A

Cytomegalovirus (CMV) / HHV-5

16
Q

Transmission: Saliva

  • INFECTIOUS MONONUCLEOSIS
  • ‘Kissing disease’
  • ✅ Monospot-positive/heterophil-positive

✅ 🐈 ✨ Downey cells

A

Epstein-Barr Virus (EBV) / HHV-4

17
Q

NOTE

Heterophil-Positive:
✅Epstein-Barr Virus

✅ Heterophil-Negative:

A

🐈

18
Q

ROSEOLA / EXANTHEM SUBITUM / SIXTH DISEASE

  • rose-colored macules
  • Nagayama spots: erythematous papules on soft palate and base of the uvula
  • CD4 site of latency

What HHV variant?

A

Human Herpesvirus 6 (HHV-6)

19
Q

HPV that causes KAPOSI SARCOMA ……AIDS-related malignancy

A

Human Herpesvirus 8 (HHV-8)

20
Q

Largest DNA virus; the only DNA virus that is complex (not icosahedral); the only DNA virus that replicates in the cytoplasm (not in the nucleus)

A

POXVIRIDAE

21
Q

causes SMALLPOX

  • Brick-shaped
  • Guarnieri bodies: intracytoplasmic eosinophilic inclusions

✅ centrifugal rash

A

Variola virus (poxviridae)

22
Q

“Dane particles”

  • Granular eosinophilic “ground glass” appearance
A

HBV

23
Q

The only positive during window period

The only positive among vaccinated patients

A

Anti-HBc IgM

24
Q
  • Councilman body
  • Granular eosinophilic “ground glass” appearance
A

HBV

25
Q

The only positive among vaccinated patients

A

Anti-HBs

26
Q

Note :

Chronic infection is characterized by the persistence of HBsAg for at least 6 months.

Persistence of HBsAg is the principal marker of risk for developing chronic liver disease and liver cancer (hepatocellular carcinoma) later in life.

Complications:
✅ HEPATIC ENCEPHALOPATHY
✅ PORTAL HYPERTENSION

A

🐈

Medical Virology (3 decks)

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