Dna Virus Drugs

Question 1

Acyclovir famicylovir and valcylcovir MOA

Answer 1

Guanosin analog,
Phosphorylated by infected cells via thymidine kinase and inhibit viral DNA polymerase by chain termination
Only used in HSV1 HSV2 VZV

Question 2

Acyclovir and others not used in CMV why

Answer 2

CMV does not contain thymidine kinase

Question 3

Side effects of acyclovir

Answer 3

Obstructive Crystalline nephropathy

Question 4

Mechanism of resistance to acyclovir and others

Answer 4

Mutation of thymidine kinase

Question 5

Gancyclovir moa

Answer 5

Phosphorylated by viral kinase and inhibits DNA polymerase

Question 6

Gancyclovir side defects

Answer 6

Nephrotixicity and myelosuppression - anemia neutropenia thrombocytopenia
Used in CMV infections

Question 7

How is valcyclovir better than Gancyclovir

Answer 7

Has better oral bioavailability

Question 8

Foscarnet MOA

Answer 8

Viral DNA/Rna polymerase inhibitor
And HIV reverse transcriptase inhibitor

Question 9

Uses of foscarnet

Answer 9

Used in CMV and HSV1&2 and VZV if resistant to previous drugs

Question 10

Side effects of foscarnet

Answer 10

Nephrotoxicity

Question 11

Cidofovir moa

Answer 11

Same as foscarnet

Question 12

Side effect of cidofovir

Answer 12

Nephrotoxicity

Question 13

Uses of cidofovir

Answer 13

CMV retinitis in immunocompromised individuals and acyclovir resistant HSV