Antifungals

Question 1

MOA OF AMPHOTERICIN B

Answer 1

Binds to ergosterol and forms channels leading to leakage of electrolytes
Acts on cell membrane

Question 2

WHAT TO GIVE W AMPHOTERICIN

Answer 2

K+ and Mg+ supplement

Question 3

Side effects of AMPHOTERICIN

Answer 3

Nephrotoxicity
Thrombophlebitis
Arrhythmia
Fever chill
Hypotension

Question 4

How to prevent nephrotoxicity in AMPHOTERICIN

Answer 4

Hydration

Question 5

Moa of nystatin

Answer 5

Same as AMPHOTERICIN B

Question 6

Uses of nystatin

Answer 6

Oral candidiasis and powder form for diaper rash

Question 7

Moa of terbinafine

Answer 7

Inhibits squalene epoxidase and prevents the formation of lanosterol

Question 8

Uses of terbinafine

Answer 8

Used in dermatophtes and onchomycosis

Question 9

Side effect of terbinafine

Answer 9

Hepatotoxicity and taste disturbance

Question 10

Moa of flucytosine

Answer 10

Inhibits DNA and RNA synthesis by converting to 5- FU by cytosine deaminase

Question 11

Side effects of flucytosine

Answer 11

Myelosuppresion

Question 12

Moa of azoles

Answer 12

Inhibits the P450 enzyme inhibits formation of ergosterol

Question 13

Side effects of azoles

Answer 13

Testosterone synthesis inhibition - gynaecomastia
Liver dysfunction
QT interval prolongation

Question 14

Moa of ecchinocandins

Answer 14

Inhibits cell wall synthesis by inhibiting beta glucan

Question 15

Uses of echinocandins

Answer 15

Invasive aspergillosis and candida

Question 16

Side effects of echinocandins

Answer 16

Histamine release causing flushing

Question 17

Moa of griseofulvin

Answer 17

Inhibits microtubule function by stopping at mitosis
Deposits in keratin containing tissues

Question 18

Side effects of griseofulvin

Answer 18

Teratogenic
Carcinogenic
Disulfiram like reaction
Increase cytochromeP450 and warfarin metabolism