DNA Virus Flashcards
Pathogenic to human with grape-like cluster with cytopathic effect in cell culture
adenovirus (mastadenovirus)
ADENOVIRUS
- common manifestion:
- acquired thru contimated respiratory _, _ and _;
- replicates in _
Respiratory and gastrointestinal;
droplets, stool, formites;
oropharynx
ADENOVIRUS
has _ serotypes
Serotype 3 and 7 –
Serotype 4 and 7 –
Serotype 8 –
Serotypes 40 and 41 –
52
Pharyngitis
Respiratory disease epidemic in military
Conjunctivitis
Gastroenteritis in children
The only DNA hepatitis;
Associated with acute hepatitis but may lead to cirrhosis
Hepadnavirus
HEPADNAVIRUS
- only source of virus:
- infectious unit:
Humans
Dane particle or Australia antigen
Hepatitis
MOT: Fecal oral
Virus (ssRNA): Picornaviridae
HAV
Hepatitis
MOT: sexual, perinatal, parental
Virus: dsDNA (Hepadnaviri dae)
HBV
Hepatitis
MOT: sharing of needles
Virus (ssRNA): Flaviviridae
HCV
Hepatitis
MOT: Intravenous drug use
Virus (ssRNA): Delta virus
HDV
Hepatitis
MOT: Fecal oral
Virus (ssRNA): Hepevirus (under Calcivirus)
HEV
Hepatitis with fecal oral MOT
HAV
HEV
Creep, presence of ulcerative lesions; Large (150-200nm)
Lifelong persistence in their host
herpes virus
Herpes virus consists of 4 components:
“CENT”
capsid,
envelope
nucleic acid core
tegument,
defined as a condition already existing but not yet active or may not cause symptoms yet
latency
Herpes Virus
Spread by direct contact with infected secretions; Recurrence of skin lesion after primary infection
HSV-1 and HSV-2
HSV-1 and HSV-2 latency
sensory nerve ganglia
HERPES VIRUS
leading cause of fatal sporadic encephalitis and corneal infection in the US.
Encephalitis in older children and adults
— other disease associated with this herpes virus
HSV-1
— Gingivostomatitis, Herpes labialis, Keratitis, pharyngitis, herpetic whitlow, encephalitis
Types Herpes Virus
HSV-1: Cold sores/ Fever blisters
HSV-2: Genital infection/ Genital Herpes
HHV-3: Varicella Zoster Virus (VZV)
HHV-4: Epstein Barr Virus (EBV)
HHV-5: Cytomegalovirus (CMV)
HHV-6 & HHV-7: Human Herpes Virus
HHV-8: Rhadinovirus
Herpes Virus
Transmitted through personal contact especially respiratory
Presence of skin rash with blisters that look like dewdrops on a rose petal
Latency:
Varicella Zoster Virus (VZV) / HHV-3
VZV latency is dorsal root ganglia
Herpes Virus
Transmitted through saliva
Causative agent of infectious mononucleosis (Glandular fever),
Burkitt lymphoma and nasopharyngeal carcinoma
Epstein Barr Virus (EBV) or HHV-4
Epstein Barr Virus (EBV) or HHV-4 is the causative agent of:
infectious mononucleosis (Glandular fever), Burkitt lymphoma and nasopharyngeal carcinoma
Herpes Virus
Salivary gland virus with owl’s eyes appearance
Transmitted through close contact with secretions, blood
transfusion (WBC), organ transplant and transplacental
Latency:
Cytomegalovirus (CMV) or HHV-5
Latency: white blood cell and endothelial cell
CMV is the most common cause of _ and _
viral mental retardation; congenital disease
Herpes Virus
Beta herpes virus
Transmitted through respiratory secretions; almost all children
from age 2-3 years old
Latency:
Human Herpes virus (HHV-6 and HHV-7)
Latency: CD4 (T Helper Cell)
Lymphotropic virus and Roseola (Exanthem subitum) – fever with
short rash
Human Herpes virus (HHV-6 and HHV-7)
Herpes Virus
Gamma herpes virus
• Kaposi Sarcoma
Rhadinovirus (HHV-8)
Cause warts and exhibit tropism in cutaneous and mucocutaneous
Papillomavirus
Type of Papillomavirus
o HPV 1 – Plantar warts
o HPV 2and 4– Warts of the Hand
o HPV 6 and 11 – Genital warts
o HPV 5 and 8 – Epidermodysplasia verruciformis
o HPV 13 and 32 – Heck’s disease (Focal epithelial hyperplasia)
o HPV 16 and 18 – Condyloma acuminate
o HPV 16 – subset of cancer of oropharynx and penile cancer in men
HPV 41 and 42 – Genital warts
Plantar Warts
HPV 1
Warts of the Hand
HPV 2 and 4
Genital Warts
HPV 6, 11, 41, 42
Epidermodysplasia verruciformis
HPV 5 and 8
Heck’s disease (Focal epithelial hyperplasia)
HPV 13 and 32
Condyloma acuminate
HPV 16 and 18
subset of cancer of oropharynx and penile cancer in men
HPV 16
Parvo = means small; smallest DNA virus
• Viral replication sites are erythroid progenitor cells, adult bone marrow
and fetal liver
• With characteristics slapped cheek appearance
Parvovirus B19
associated with Erythema infectiosum
Parvovirus B19
POLYOMA VIRUS
Hemorrhagic cystitis;
latent state in kidney
BK virus / Polyoma virus hominis 1
POLYOMA VIRUS
Progressive multifocal leukoencelopathy;
latent state in B lymphocyte
JC virus / Polyoma virus hominis 2
POLYOMA VIRUS
associated with Merkel Cell Carcinoma
MC Virus
Largest and most complex of all viruses
Oval or brick shape virus
Poxvirus
POXVIRUS
_ — absent or virulence, used in smallpox vaccine; causes cowpox
Vaccinia
POXVIRUS
causative agent of smallpox virus
Variola/Orthopoxvirus
POXVIRUS
small, pink, popular wart-like benign
tumors of the skin or mucous membrane
Molluscum Contangiosum
POXVIRUS
transmitted by direct contact with sheep in which nodules in hands may be seen
Orf virus
Large dsDNA virus which is the causative agent of African Swine Flu (ASF)
Not transmissible to human but highly pathogenic to pigs (causes
hemorrhagic fever to them)
Known to be transmitted by arthropods (soft ticks)
Iridovirus
nasopharyngeal carcinoma causative agent
HHV - 4 (Epstein)
