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Molecular Biochemistry > DNA Replication > Flashcards

DNA Replication Flashcards

1
Q

Function of helicase

A

unwinding of dna at replication fork

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2
Q

Disease in deficiency of helicase

A

Bloom Syndrome

due to mutation of BLM gene

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3
Q

Function of SSBP

A

prevent strand from reannealing or degradation

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4
Q

Function of DNA topoisomerase

A

Removal of supercoils

Topo 1 - single stranded breaks
topo 2 - double strand breaks

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5
Q

Inhibitors of top 1 (eu)

A

EU top 1 - irinotecan; topotecan

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6
Q

Inhibitors of top 2 (eu)

A

etoposide; teniposide

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7
Q

inhibitors of top 2 (pro)

A

fluoroquinolones

top2 in pro is DNA gyrase and inhibits top 4

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8
Q

Function of primase

A

make RNA primer

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9
Q

DNA Pol III

A

Adds dna to 3’ end

polymerisation towards 3’ and proofreadind towards 5’

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10
Q

DNA Pol I

A

Degrades RNA primer

same function as dna pol 3 and proofread towards 5’

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11
Q

DNA ligase

A

formation of PDE

joins okazaki fragments

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12
Q

Telomerase

A

Reverse transcriptase adds dna to 3’

to prevent genetic loss

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13
Q

Telomerase is _____ in cancer

A

Upregulated

also in progenitor cells

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14
Q

Telomerase is _____ in aging

A

Downregulated

also in progeria

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15
Q

Leading strand goes from __ to __

A

3’ to 5’

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16
Q

Prokaryotic exclusive enzymes

A

DNA pol 1
DNA pol 3

telomerase only in eukaryotes

17
Q

_____are required for both the leading and lagging strands of the DNA molecule being transcribed.

A

Primers

18
Q

______ is the enzyme that breaks the phosphodiester bond of one DNA strand backbone to facilitate unwinding of the helical strands for DNA replication or transcription.

A

Type 1 Topoisomerase

Molecular Biochemistry (6 decks)

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