Nucleotide metabolism Flashcards
1
Q
Ribose 5 phosphate to _____ by _______
A
PRPP by Ribose Phosphate Pyrophosphokinase
2
Q
Glutamate to carbamoyl phosphate
A
CPS 2
3
Q
ATCase reaction
A
Carbamoyl phosphate to carbamoyl Aspartic acid
4
Q
Carbamoyl aspartic acid to _____ by ______
A
orotate by dihydroorotase
5
Q
orotate to orotidine monophosphate
A
orotate phosphoribosyl transferase {PRPP attaches here}
6
Q
OMP to UMP by
A
UMP synthase
7
Q
UMP to
A
CTP
8
Q
CDP to dCDP
A
Ribonucleotide diphosphate reductase
9
Q
Carbamoyl phosphate to orotic acid is blocked by
A
Leflunomide - inhibit dihydroorotate dehydrogenase
10
Q
Orotic Aciduria
A
type 2 - def of enz ump synthase
type 1 - def of both ump synthase and oprt
