DNA Repair

Question 1

What type of damage would the ‘DNA mismatch repair pathway’ repair?

Answer 1

Errors made during replication

Question 2

What type of error would ‘nucleotide excision’ repair?

Answer 2

Large bulky lesions

Question 3

What type of error would the ‘homology dependant repair pathway’ repair, and how does this work?

Answer 3

Double stranded breaks

Repairs using information from the sister chromatid or homologous chromosome

Question 4

What type of error would the ‘non-homologous end joining’ pathway repair?

Answer 4

Double stranded breaks in non dividing somatic cells

Question 5

Name two syndromes which could be caused by defects in nucleotide excision repair?

Answer 5

Xeroderma pigmentosum and Cockayne syndrome

Question 6

What type of cancer is associated with inherited mutations in the mismatch repair pathway?

Answer 6

Hereditary non-polyposis colon cancer

Question 7

What problems could be caused by defects in the repair of double stranded breaks?

Answer 7

Nijmegen syndrome and predisposition to breast and ovarian cancer